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Zinc ionophores: chemistry and biological applications.
Scavo, Simone; Oliveri, Valentina.
  • Scavo S; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, v.le A. Doria 6, 95125 Catania, Italy.
  • Oliveri V; Dipartimento di Scienze Chimiche, Università degli Studi di Catania, v.le A. Doria 6, 95125 Catania, Italy. Electronic address: valentina.oliveri@unict.it.
J Inorg Biochem ; 228: 111691, 2022 03.
Article in English | MEDLINE | ID: covidwho-1558451
ABSTRACT
Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. This evidence justifies the efforts in applying Zinc ionophores to restore Zinc homeostasis and treat bacterial/viral infections such as coronavirus diseases. Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. This review provides, for the first time, an overview of the applications of the main Zinc ionophores in Zinc deficiency, infectious diseases, and in cancer, discussing the pharmacological and coordination properties of the Zinc ionophores.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Zinc / Communicable Diseases / Ionophores / Neoplasms Limits: Humans Language: English Journal: J Inorg Biochem Year: 2022 Document Type: Article Affiliation country: J.jinorgbio.2021.111691

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Zinc / Communicable Diseases / Ionophores / Neoplasms Limits: Humans Language: English Journal: J Inorg Biochem Year: 2022 Document Type: Article Affiliation country: J.jinorgbio.2021.111691