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Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans.
Zickler, Martin; Stanelle-Bertram, Stephanie; Ehret, Sandra; Heinrich, Fabian; Lange, Philine; Schaumburg, Berfin; Kouassi, Nancy Mounogou; Beck, Sebastian; Jaeckstein, Michelle Y; Mann, Oliver; Krasemann, Susanne; Schroeder, Maria; Jarczak, Dominik; Nierhaus, Axel; Kluge, Stefan; Peschka, Manuela; Schlüter, Hartmut; Renné, Thomas; Pueschel, Klaus; Kloetgen, Andreas; Scheja, Ludger; Ondruschka, Benjamin; Heeren, Joerg; Gabriel, Guelsah.
  • Zickler M; Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Stanelle-Bertram S; Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Ehret S; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Heinrich F; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Lange P; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schaumburg B; Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Kouassi NM; Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Beck S; Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Jaeckstein MY; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Mann O; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Krasemann S; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany.
  • Schroeder M; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Jarczak D; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Nierhaus A; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Kluge S; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Peschka M; Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schlüter H; Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Renné T; Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Pueschel K; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Kloetgen A; Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Scheja L; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Ondruschka B; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: heeren@uke.de.
  • Gabriel G; Leibniz Institute for Experimental Virology, Hamburg, Germany; Institute for Virology, University for Veterinary Medicine Hanover, Hanover, Germany. Electronic address: guelsah.gabriel@leibniz-hpi.de.
Cell Metab ; 34(1): 1-2, 2022 01 04.
Article in English | MEDLINE | ID: covidwho-1559077
ABSTRACT
Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Adipose Tissue / Lipid Metabolism / SARS-CoV-2 / COVID-19 / Liver / Lung Limits: Animals / Female / Humans / Male Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2022 Document Type: Article Affiliation country: J.cmet.2021.12.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Adipose Tissue / Lipid Metabolism / SARS-CoV-2 / COVID-19 / Liver / Lung Limits: Animals / Female / Humans / Male Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2022 Document Type: Article Affiliation country: J.cmet.2021.12.002