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Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection.
Winkler, Martin Sebastian; Claus, Ralf Alexander; Schilder, Mareike; Pöhlmann, Stefan; Coldewey, Sina M; Grundmann, Julian; Fricke, Torben; Moerer, Onnen; Meissner, Konrad; Bauer, Michael; Hofmann-Winkler, Heike; Gräler, Markus H.
  • Winkler MS; Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
  • Claus RA; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
  • Schilder M; Center for Molecular Biomedicine (CMB), Jena University Hospital, Jena, Germany.
  • Pöhlmann S; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
  • Coldewey SM; Center for Molecular Biomedicine (CMB), Jena University Hospital, Jena, Germany.
  • Grundmann J; Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
  • Fricke T; Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany.
  • Moerer O; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
  • Meissner K; Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
  • Bauer M; Septomics Research Center, Jena University Hospital, Jena, Germany.
  • Hofmann-Winkler H; Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
  • Gräler MH; Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
Clin Sci (Lond) ; 135(24): 2781-2791, 2021 12 22.
Article in English | MEDLINE | ID: covidwho-1599254
ABSTRACT
Low plasma levels of the signaling lipid metabolite sphingosine 1-phosphate (S1P) are associated with disrupted endothelial cell (EC) barriers, lymphopenia and reduced responsivity to hypoxia. Total S1P levels were also reduced in 23 critically ill patients with coronavirus disease 2019 (COVID-19), and the two main S1P carriers, serum albumin (SA) and high-density lipoprotein (HDL) were dramatically low. Surprisingly, we observed a carrier-changing shift from SA to HDL, which probably prevented an even further drop in S1P levels. Furthermore, intracellular S1P levels in red blood cells (RBCs) were significantly increased in COVID-19 patients compared with healthy controls due to up-regulation of S1P producing sphingosine kinase 1 and down-regulation of S1P degrading lyase expression. Cell culture experiments supported increased sphingosine kinase activity and unchanged S1P release from RBC stores of COVID-19 patients. These observations suggest adaptive mechanisms for maintenance of the vasculature and immunity as well as prevention of tissue hypoxia in COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sphingosine / Lysophospholipids / Erythrocytes / COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Humans Language: English Journal: Clin Sci (Lond) Year: 2021 Document Type: Article Affiliation country: Cs20210666

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sphingosine / Lysophospholipids / Erythrocytes / COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Humans Language: English Journal: Clin Sci (Lond) Year: 2021 Document Type: Article Affiliation country: Cs20210666