Flavivirus-host interactions: an expanding network of proviral and antiviral factors.
Curr Opin Virol
; 52: 71-77, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1936243
ABSTRACT
Flaviviruses are zoonotic pathogens transmitted by the bite of infected mosquitos and ticks and represent a constant burden to human health. Here we review recent literature aimed at uncovering how flaviviruses interact with the cells that they infect. A better understanding of these interactions may ultimately lead to novel therapeutic targets. We highlight several studies that employed low-biased methods to discover new protein-protein, protein-RNA, and genetic interactions, and spotlight recent work characterizing the host protein, TMEM41B, which has been shown to be critical for infection by diverse flaviviruses and coronaviruses.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Flavivirus Infections
/
Flavivirus
Limits:
Animals
/
Humans
Language:
English
Journal:
Curr Opin Virol
Year:
2022
Document Type:
Article
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