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Retinal Vein Occlusion Following Two Doses of mRNA-1237 (Moderna) Immunization for SARS-Cov-2: A Case Report.
Sacconi, Riccardo; Simona, Filippo; Forte, Paolo; Querques, Giuseppe.
  • Sacconi R; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • Simona F; Ophthalmology Unit, Division of Head and Neck, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Forte P; Pax Eye Center, Via Stazione 9, 6600, Locarno, Switzerland.
  • Querques G; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Ophthalmol Ther ; 11(1): 453-458, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1559807
ABSTRACT

INTRODUCTION:

Published data on possible ocular adverse events potentially associated with vaccination with the SARS-Cov-2 mRNA-1237 vaccine are scarce. In this report, we describe the case of a patient who had a hemispheric retinal vein occlusion potentially associated with being vaccinated with the second dose of the SARS-Cov-2 mRNA-1237 vaccine.

METHODS:

Case report including a discussion on multimodal imaging.

RESULTS:

A 74-year-old woman presented with painless vision loss in the right eye experienced 48 hours after receiving a second dose of the mRNA-1237 vaccine. The patient was receiving oral anticoagulant therapy for atrial fibrillation. Her best-corrected visual acuity (VA) was 20/32, and fundus examination showed venous congestion and widespread blot haemorrhages in the inferior quadrants. Based on multimodal imaging evaluation, the diagnosis of hemispheric retinal vein occlusion was made. Due to the development of cystoid macular oedema with intraretinal fluid and the decline in VA, the patient was treated with two injections of intravitreal ranibizumab, leading to functional improvement and regression of oedema.

CONCLUSIONS:

We report a case with retinal vein occlusion 48 hours after vaccination with the SARS-Cov-2 mRNA-1237 vaccine; however, the relationship between these two events remains unclear. Further research is warranted to better understand the potential link between retinal thrombotic events and vaccination.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Experimental Studies Topics: Vaccines Language: English Journal: Ophthalmol Ther Year: 2022 Document Type: Article Affiliation country: S40123-021-00441-3

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Experimental Studies Topics: Vaccines Language: English Journal: Ophthalmol Ther Year: 2022 Document Type: Article Affiliation country: S40123-021-00441-3