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Multi-omics approach to COVID-19: a domain-based literature review.
Montaldo, Chiara; Messina, Francesco; Abbate, Isabella; Antonioli, Manuela; Bordoni, Veronica; Aiello, Alessandra; Ciccosanti, Fabiola; Colavita, Francesca; Farroni, Chiara; Najafi Fard, Saeid; Giombini, Emanuela; Goletti, Delia; Matusali, Giulia; Rozera, Gabriella; Rueca, Martina; Sacchi, Alessandra; Piacentini, Mauro; Agrati, Chiara; Fimia, Gian Maria; Capobianchi, Maria Rosaria; Lauria, Francesco Nicola; Ippolito, Giuseppe.
  • Montaldo C; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Messina F; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Abbate I; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Antonioli M; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Bordoni V; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Aiello A; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Ciccosanti F; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Colavita F; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Farroni C; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Najafi Fard S; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Giombini E; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Goletti D; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Matusali G; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Rozera G; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Rueca M; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Sacchi A; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Piacentini M; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Agrati C; Dept. Biology, University of Rome Tor Vergata, Via della Ricerca scientifica 1, Rome, Italy.
  • Fimia GM; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Capobianchi MR; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy.
  • Lauria FN; Dept. Molecular Medicine, Sapienza University of Rome, 00185, Rome, Italy.
  • Ippolito G; National Institute for Infectious Diseases, "Lazzaro Spallanzani" - IRCCS, Via Portuense, 292, 00149, Rome, Italy. maria.capobianchi@inmi.it.
J Transl Med ; 19(1): 501, 2021 12 07.
Article in English | MEDLINE | ID: covidwho-1560461
ABSTRACT

BACKGROUND:

Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as well as that of cell types and organs, in the pathophysiology of COVID-19, and to highlight their links with clinical phenotypes of SARS-CoV-2 infection.

METHODS:

The analysis was based on the domain model, where for domain it is intended a conceptual repository, useful to summarize multiple biological pathways involved at different levels. The relevant domains considered in the analysis were virus, pathways and phenotypes. An interdisciplinary expert working group was defined for each domain, to carry out an independent literature scoping review.

RESULTS:

The analysis revealed that dysregulated pathways of innate immune responses, (i.e., complement activation, inflammatory responses, neutrophil activation and degranulation, platelet degranulation) can affect COVID-19 progression and outcomes. These results are consistent with several clinical studies.

CONCLUSIONS:

Multi-omics approach may help to further investigate unknown aspects of the disease. However, the disease mechanisms are too complex to be explained by a single molecular signature and it is necessary to consider an integrated approach to identify hallmarks of severity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: J Transl Med Year: 2021 Document Type: Article Affiliation country: S12967-021-03168-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: J Transl Med Year: 2021 Document Type: Article Affiliation country: S12967-021-03168-8