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Myocarditis and COVID-19 mRNA vaccines: a mechanistic hypothesis involving dsRNA.
Milano, Gerard; Gal, Jocelyn; Creisson, Anne; Chamorey, Emmanuel.
  • Milano G; Centre Antoine Lacassagne, Unité Propre de Recherche 7497, Université Côte d'Azur, 06100, Nice, France.
  • Gal J; Centre Antoine Lacassagne, UNS EA 7497 Nice University, 33 Avenue de Valombrose, 06189, Nice, France.
  • Creisson A; Centre Antoine Lacassagne, UNS EA 7497 Nice University, 33 Avenue de Valombrose, 06189, Nice, France.
  • Chamorey E; Epidemiology & Biostatistics Department, Centre Antoine Lacassagne, University Côte d'Azur, 33 Avenue de Valombrose, 06189, Nice, France.
Future Virol ; 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1560505
ABSTRACT
While tolerance to COVID-19 vaccination is considered satisfactory, a phenomenon of myocarditis, although rare, is becoming a safety concern in mRNA COVID-19 vaccination. The presence of low residual levels of double-strand RNA (dsRNA) has been reported in mRNA COVID-19 vaccine preparations. dsRNA is a known inducer of immune-inflammatory reactions. dsRNA present in vaccine nanoparticles may be suspected to be at the origin of the still unexplained cases of myocarditis.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0280

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0280