Invasive Pulmonary Aspergillosis and Tuberculosis Complicated by Hemophagocytic Lymphohistiocytosis - Sequelae of COVID-19 in a Liver Transplant Recipient.

Gandotra, Akash; Mehtani, Rohit; Premkumar, Madhumita; Duseja, Ajay; De, Arka; Mallik, Nabhajit; Durgadevi, S; Das, Ashim; Kalra, Naveen

Gandotra, Akash; Mehtani, Rohit; Premkumar, Madhumita; Duseja, Ajay; De, Arka; Mallik, Nabhajit; Durgadevi, S; Das, Ashim; Kalra, Naveen.

Gandotra A; Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Mehtani R; Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Premkumar M; Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Duseja A; Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
De A; Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Mallik N; Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Durgadevi S; Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Das A; Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Kalra N; Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

J Clin Exp Hepatol ; 12(3): 1007-1011, 2022.

Article in English | MEDLINE | ID: covidwho-1561499

ABSTRACT

ABSTRACT

Liver transplant recipients are at an increased risk of opportunistic infections due to the use of immunosuppression. Coronavirus disease of 2019 (COVID-19) increases the risk of these infections further due to associated immune dysfunction and the use of high-dose steroids. We present a case of a liver transplant recipient who developed disseminated tuberculosis and invasive pulmonary aspergillosis complicated by acquired hemophagocytic lymphohistiocytosis after recovering from severe COVID-19.

Keywords

AFB, Acid-fast bacilli; AKI, Acute kidney Injury; ATT, Antitubercular therapy; BDG, Beta-D Glucan; COVID-19; COVID-19, Coronavirus disease of 2019; DEB-TACE, Drug eluting bead transarterial chemoembolization; GM, Galactomannan; HCC, Hepatocellular Carcinoma; HLH, Hemophagocytic Lymphohistiocytosis; HRCT, High-resolution computed tomography; IDSA, Infectious Diseases Society of America; IPA, Invasive pulmonary aspergillosis; IVIg, Intravenous immunoglobulin; NODAT, New onset diabetes after transplant; PAS, Periodic acid Schiff; RT-PCR, Reverse transcriptase-polymerase chain reaction; SARS-CoV-2, Severe acute respiratory syndrome corona virus 2; disseminated tuberculosis; hemophagocytic lymphohistiocytosis; invasive aspergillosis; liver transplantation; mRECIST, modified response evaluation criteria in solid tumors; sHLH, Secondary hemophagocytic lymphohistiocytosis

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Long Covid Language: English Journal: J Clin Exp Hepatol Year: 2022 Document Type: Article Affiliation country: J.jceh.2021.12.002

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