The Effect of Local and Global Interventions on Epidemic Spreading.
Int J Environ Res Public Health
; 18(23)2021 11 30.
Article
in English
| MEDLINE | ID: covidwho-1561608
ABSTRACT
Epidemic spreading causes severe challenges to the global public health system, and global and local interventions are considered an effective way to contain such spreading, including school closures (local), border control (global), etc. However, there is little study on comparing the efficiency of global and local interventions on epidemic spreading. Here, we develop a new model based on the Susceptible-Exposed-Infectious-Recovered (SEIR) model with an additional compartment called "quarantine status". We simulate various kinds of outbreaks and interventions. Firstly, we predict, consistent with previous studies, interventions reduce epidemic spreading to 16% of its normal level. Moreover, we compare the effect of global and local interventions and find that local interventions are more effective than global ones. We then study the relationships between incubation period and interventions, finding that early implementation of rigorous intervention significantly reduced the scale of the epidemic. Strikingly, we suggest a Pareto optimal in the intervention when resources were limited. Finally, we show that combining global and local interventions is the most effective way to contain the pandemic spreading if initially infected individuals are concentrated in localized regions. Our work deepens our understandings of the role of interventions on the pandemic, and informs an actionable strategy to contain it.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Ijerph182312627
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