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Efficacy of chloroquine and hydroxychloroquine for the treatment of hospitalized COVID-19 patients: a meta-analysis.
Deng, Jiawen; Zhou, Fangwen; Heybati, Kiyan; Ali, Saif; Zuo, Qi Kang; Hou, Wenteng; Dhivagaran, Thanansayan; Ramaraju, Harikrishnaa Ba; Chang, Oswin; Wong, Chi Yi; Silver, Zachary.
  • Deng J; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Zhou F; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Heybati K; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Ali S; Mayo Clinic Alix School of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
  • Zuo QK; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Hou W; Department of Anesthesiology, Rutgers, New Jersey Medical School, 185 S Orange Ave, Newark, NJ 07103, USA.
  • Dhivagaran T; Faculty of Science, McGill University, 845 Sherbrooke St W, Montreal, QC, H3A 0G5, Canada.
  • Ramaraju HB; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Chang O; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Wong CY; Integrated Biomedical Engineering & Health Sciences Program (iBioMed), McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
  • Silver Z; Faculty of Health Sciences, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada.
Future Virol ; 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1561748
ABSTRACT

Aims:

To evaluate the efficacy and safety of hydroxychloroquine/chloroquine, with or without azithromycin, in treating hospitalized COVID-19 patients. Materials &

methods:

Data from randomized and observational studies were included in a random-effects meta-analysis. Primary outcomes included time to negative conversion of SARS-CoV-2 tests, length of stay, mortality, incidence of mechanical ventilation, time to normalization of body temperature, incidence of adverse events and incidence of QT prolongations.

Results:

Fifty-one studies (n = 61,221) were included. Hydroxychloroquine/chloroquine showed no efficacy in all primary efficacy outcomes, but was associated with increased odds of QT prolongations.

Conclusion:

Due to a lack of efficacy and increased odds of cardiac adverse events, hydroxychloroquine/chloroquine should not be used for treating hospitalized COVID-19 patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials / Reviews Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0119

Full text: Available Collection: International databases Database: MEDLINE Type of study: Randomized controlled trials / Reviews Language: English Year: 2021 Document Type: Article Affiliation country: Fvl-2021-0119