The effects of the antecedent use of inhaled steroid on the clinical course of COVID-19: A retrospective study of asthmatic patients.
J Infect Public Health
; 15(1): 56-64, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-1562368
ABSTRACT
BACKGROUND:
There is conflicting evidence regarding the effect of asthma and its different therapeutic options on COVID-19 severity and the clinical outcomes.AIM:
This study aimed to investigate the relationship between using inhaled corticosteroids (ICS) by asthmatic patients and the severity of COVID-19. MATERIALS ANDMETHODS:
This retrospective observational study was conducted from March 15 to October 23, 2020 and included data of all COVID-19 asthmatic patients (nâ¯=â¯287) at King Abdulaziz Medical City. Twelve patients were excluded due to poor medication history documentation or using ICS for non-asthma indication. Ordinal logistic regression was used to determine the clinical variables that affect COVID-19 severity. The clinical outcomes of ICS and non-ICS users were compared.RESULTS:
Of the sample (nâ¯=â¯275), 198 (72%) were using ICS therapy. No significant difference was found between ICS and non-ICS users in disease severity (Pâ¯=â¯0.12), mortality (Pâ¯=â¯0.45), ICU admission (Pâ¯=â¯0.78), and the occurrence of complications. However, the number of days on ventilation were significantly increased in ICS users (Pâ¯=â¯0.006). Being prescribed the ICS/LABA combination (adj OR 0.72 [0.15,1.2]; Pâ¯=â¯0.021), being hypertensive (adj OR 0.98 [0.28,1.6]; Pâ¯=â¯0.006), having cancer (adj OR 1.49 [0.12, 2.8]; Pâ¯=â¯0.033), or having diabetes (adj OR 0.75 [0.09, 1.4]; Pâ¯=â¯0.024) could not increase the risk for more severe disease.CONCLUSION:
Overall, ICS therapy did not alter the COVID-19 severity or mortality in asthmatic patients. The continued use of ICS during the pandemic should be encouraged to prevent asthma exacerbations.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
/
Anti-Asthmatic Agents
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Infect Public Health
Journal subject:
Communicable Diseases
/
Public Health
Year:
2022
Document Type:
Article
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