Evidence for increased SARS-CoV-2 susceptibility and COVID-19 severity related to pre-existing immunity to seasonal coronaviruses

Wratil, Paul R.; Schmacke, Niklas A.; Karakoc, Burak, Dulovic, Alex, Junker, Daniel, Becker, Matthias, Rothbauer, Ulrich, Osterman, Andreas, Spaeth, Patricia M.; Ruhle, Adrian, Gapp, Madeleine, Schneider, Stephanie, Muenchhoff, Maximilian, Hellmuth, Johannes C.; Scherer, Clemens, Mayerle, Julia, Reincke, Martin, Behr, Juergen, Kääb, Stefan, Zwissler, Bernhard, von Bergwelt-Baildon, Michael, Eberle, Josef, Kaderali, Lars, Schneiderhan-Marra, Nicole, Hornung, Veit, Keppler, Oliver T.

Wratil, Paul R.; Schmacke, Niklas A.; Karakoc, Burak, Dulovic, Alex, Junker, Daniel, Becker, Matthias, Rothbauer, Ulrich, Osterman, Andreas, Spaeth, Patricia M.; Ruhle, Adrian, Gapp, Madeleine, Schneider, Stephanie, Muenchhoff, Maximilian, Hellmuth, Johannes C.; Scherer, Clemens, Mayerle, Julia, Reincke, Martin, Behr, Juergen, Kääb, Stefan, Zwissler, Bernhard, von Bergwelt-Baildon, Michael, Eberle, Josef, Kaderali, Lars, Schneiderhan-Marra, Nicole, Hornung, Veit, Keppler, Oliver T..

Cell reports ; 2021.

Article in English | EuropePMC | ID: covidwho-1565013

ABSTRACT

ABSTRACT

Wratil et al. find specific antibody responses against seasonal human coronaviruses, which cause the common cold, to be elevated in patients with COVID-19 compared to pre-pandemic blood donors. This specific immunity is likely pre-existing in patients and increases their susceptibility to SARS-CoV-2 and severity of COVID-19.

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Collection: Databases of international organizations Database: EuropePMC Type of study: Prognostic study Language: English Journal: Cell reports Year: 2021 Document Type: Article

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