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Uptake and adverse reactions of COVID-19 vaccination among people living with HIV in China: a case-control study.
Zhao, Heping; Wang, Hui; Li, Hui; Zheng, Weiran; Yuan, Tanwei; Feng, Anping; Luo, Dan; Hu, Yuqing; Sun, Yinghui; Lin, Yi-Fan; Zhou, Yiguo; Luo, Ganfeng; Peng, Qiaoli; Yang, Jianzhou; Xu, Junjie; Zou, Huachun.
  • Zhao H; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Wang H; National Clinical Research Center for Infectious Diseases, The Third People' S Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Li H; Shizhong District Center for Disease Control and Prevention, Jinan, China.
  • Zheng W; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Yuan T; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Feng A; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Luo D; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Hu Y; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Sun Y; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Lin YF; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Zhou Y; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Luo G; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
  • Peng Q; National Clinical Research Center for Infectious Diseases, The Third People' S Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Yang J; Department of Preventive Medicine, Changzhi Medical College, Changzhi, Shanxi, China.
  • Xu J; Clinical Research Academy, Peking University Shenzhen Hospital, Peking University, China.
  • Zou H; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, PR China.
Hum Vaccin Immunother ; 17(12): 4964-4970, 2021 12 02.
Article in English | MEDLINE | ID: covidwho-1565873
ABSTRACT

OBJECTIVES:

The coronavirus disease-2019 (COVID-19) pandemic continues to ravage the world. People living with HIV (PLHIV) are one of the most vulnerable groups. This study aims to identify the factors associated with the uptake and adverse reactions of COVID-19 vaccination.

METHODS:

We recruited PLHIV in China by convenience sampling between 7 and 23 February 2021. Participants were asked to complete an online questionnaire. Chi-squared test and multivariable logistic regression were used to assess factors associated with vaccine uptake.

RESULTS:

A total of 527 vaccinated and 1091 unvaccinated PLHIV were recruited. Individuals who had a higher education, engaged in occupations with a higher risk of COVID-19 infection, received influenza or pneumonia vaccine in the past 3 years (5.40, 3.36-8.77), believed in the effectiveness of vaccines (3.01, 2.20-4.12), and received media information regarding COVID-19 vaccine (2.23, 1.61-3.11), were more likely to be vaccinated. Concerning about adverse reactions (0.31, 0.22-0.44), negative impact on the progression of HIV/AIDS (0.36, 0.26-0.50) or antiretroviral therapy (ART) (0.61, 0.44-0.85), disclosure of HIV infection status (0.69, 0.49-0.96), comorbidities (0.33, 0.22-0.47), being unmarried (0.43, 0.28-0.66) and older age were negatively associated with vaccination. Of the 527 vaccinated PLHIV, 155 (29.4%) PLHIV reported adverse reactions, with pain at the injection site being the most common (18.2%).

CONCLUSIONS:

PLHIV, who are concerned about adverse reactions, negative impact on ART outcome and disclosure of HIV infection status, were less likely to adopt COVID-19 vaccination. To increase vaccination coverage among PLHIV, health-care professionals should emphasize the benefits and necessity of vaccination and provide consultancy regarding adverse reactions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / HIV Infections / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid / Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / HIV Infections / COVID-19 Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Topics: Long Covid / Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article