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Host predictors of broadly cross-reactive antibodies against SARS-CoV-2 variants of concern differ between infection and vaccination.
Tang, Li; Cherry, Sean; Tuomanen, Elaine I; Roubidoux, Ericka Kirkpatrick; Lin, Chun-Yang; Allison, Kim J; Gowen, Ashleigh; Freiden, Pamela; Allen, E Kaitlynn; Su, Yin; Gaur, Aditya H; Estepp, Jeremie H; McGargill, Maureen A; Krammer, Florian; Thomas, Paul G; Schultz-Cherry, Stacey; Wolf, Joshua.
  • Tang L; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Cherry S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Tuomanen EI; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Roubidoux EK; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Lin CY; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Allison KJ; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Gowen A; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Freiden P; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Allen EK; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Su Y; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Gaur AH; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Estepp JH; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • McGargill MA; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Krammer F; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Thomas PG; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Schultz-Cherry S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Wolf J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.
Clin Infect Dis ; 2021 Dec 10.
Article in English | MEDLINE | ID: covidwho-1566002
ABSTRACT

BACKGROUND:

Following SARS-CoV-2 infection or vaccination there is significant variability between individuals in protective antibody levels against SARS-CoV-2, and within individuals against different virus variants. However, host demographic or clinical characteristics that predict variability in cross-reactive antibody levels are not well-described. These data could inform clinicians, researchers, and policy makers on the populations most likely to require vaccine booster shots.

METHODS:

In an institutional review board-approved prospective observational cohort study of staff at St. Jude Children's Research Hospital, we identified participants with plasma samples collected after SARS-CoV-2 infection, after mRNA vaccination, and after vaccination following infection, and quantitated IgG levels by ELISA to the spike receptor binding domain (RBD) from five important SARS-CoV-2 variants (Wuhan Hu-1, B.1.1.7, B.1.351, P.1 and B.1.617.2). We used regression models to identify factors that contributed to cross-reactive IgG against one or multiple viral variants.

RESULTS:

Following infection, a minority of the cohort generated cross-reactive antibodies, IgG antibodies that bound all tested variants. Those that did had increased disease severity, poor metabolic health, and were of a particular ancestry. Vaccination increased the levels of cross-reactive IgG levels in all populations including immunocompromised, elderly and persons with poor metabolic health. Younger people with a healthy weight mounted the highest responses.

CONCLUSIONS:

Our findings provide important new information on individual antibody responses to infection/vaccination that could inform clinicians on the populations that may require follow-on immunization.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid