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Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation.
Rocco, Joseph M; Mallarino-Haeger, Christina; Randolph, Attiya H; Ray, Susan M; Schechter, Marcos C; Zerbe, Christa S; Holland, Steven M; Sereti, Irini.
  • Rocco JM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Mallarino-Haeger C; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Randolph AH; Department of Medicine, George Washington University of Medicine and Health Sciences, Washington, DC, USA.
  • Ray SM; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Schechter MC; Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
  • Zerbe CS; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Holland SM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Sereti I; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Clin Infect Dis ; 75(1): e912-e915, 2022 Aug 24.
Article in English | MEDLINE | ID: covidwho-2017798
ABSTRACT
The development of effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines has been a significant accomplishment. Adverse events are extremely rare, but continued surveillance is important, especially in at-risk populations. In 5 patients with preexisting immune dysregulation, hyperinflammatory syndromes, including hemophagocytic lymphohistiocytosis, developed after SARS-CoV-2 mRNA vaccination. Early recognition of this rare condition is essential.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Middle East Respiratory Syndrome Coronavirus / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Middle East Respiratory Syndrome Coronavirus / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid