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Immunogenicity of SCB-2019 Coronavirus Disease 2019 Vaccine Compared With 4 Approved Vaccines.
Ambrosino, Donna; Han, Htay Htay; Hu, Branda; Liang, Joshua; Clemens, Ralf; Johnson, Marina; Siber, George; Goldblatt, David.
  • Ambrosino D; Independent Advisor, Stuart, Florida, USA.
  • Han HH; Clover Biopharmaceuticals, Chengdu, China.
  • Hu B; Clover Biopharmaceuticals, Chengdu, China.
  • Liang J; Clover Biopharmaceuticals, Chengdu, China.
  • Clemens R; Global Research in Infectious Diseases, Rio de Janeiro, Brazil.
  • Johnson M; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
  • Siber G; Independent Advisor, New York, New York, USA.
  • Goldblatt D; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
J Infect Dis ; 225(2): 327-331, 2022 01 18.
Article in English | MEDLINE | ID: covidwho-1566021
ABSTRACT
A significant correlation has been shown between the binding antibody responses against original severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and vaccine efficacy of 4 approved coronavirus disease 2019 vaccines. We therefore assessed the immune response against original SARS-CoV-2 elicited by the adjuvanted S-Trimer vaccine, SCB-2019 + CpG/alum, in the same assay and laboratory. Responses to SCB-2019 were comparable or superior for antibody to original and Alpha variant when compared with 4 approved vaccines. The comparison accurately predicted success of the recently reported efficacy trial of SCB-2019 vaccine. Immunogenicity comparisons to original strain and variants of concern should be considered as a basis for authorization of vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / Immunogenicity, Vaccine / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / Immunogenicity, Vaccine / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis