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Performance comparison of micro-neutralization assays based on surrogate SARS-CoV-2 and WT SARS-CoV-2 in assessing virus-neutralizing capacity of anti-SARS-CoV-2 antibodies.
Sekirov, Inna; Petric, Martin; Carruthers, Erin; Lawrence, David; Pidduck, Tamara; Kustra, Jesse; Laley, Jonathan; Lee, Min-Kuang; Chahil, Navdeep; Mak, Annie; Levett, Paul N; Mendoza, Emelissa; Wood, Heidi; Drebot, Mike; Krajden, Mel; Morshed, Muhammad.
  • Sekirov I; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Petric M; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Carruthers E; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Lawrence D; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Pidduck T; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Kustra J; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Laley J; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Lee MK; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Chahil N; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Mak A; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Levett PN; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Mendoza E; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Wood H; British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, British Columbia, Canada.
  • Drebot M; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Krajden M; National Microbiology Laboratory, Winnipeg, Manitoba, Canada.
  • Morshed M; National Microbiology Laboratory, Winnipeg, Manitoba, Canada.
Access Microbiol ; 3(8): 000257, 2021.
Article in English | MEDLINE | ID: covidwho-1566108
ABSTRACT
We compared neutralization assays using either the wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus or surrogate neutralization markers, using characterized sera. We found the results of the neutralization assays 75 % concordant overall and 80 % concordant for samples with high antibody levels. This demonstrates that commercial surrogate SARS-CoV-2 assays offer the potential to assess anti-SARS-CoV-2 antibodies' neutralizing capacity outside CL-3 laboratory containment.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Access Microbiol Year: 2021 Document Type: Article Affiliation country: Acmi.0.000257

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Access Microbiol Year: 2021 Document Type: Article Affiliation country: Acmi.0.000257