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Unexplained arterial thrombosis: approach to diagnosis and treatment.
May, Jori E; Moll, Stephan.
  • May JE; Department of Medicine, Division of Hematology/Oncology, University of Alabama at Birmingham, Birmingham, AL.
  • Moll S; Department of Medicine, Division of Hematology, University of North Carolina School of Medicine, Chapel Hill, NC.
Hematology Am Soc Hematol Educ Program ; 2021(1): 76-84, 2021 12 10.
Article in English | MEDLINE | ID: covidwho-1566496
ABSTRACT
Arterial thrombotic events in younger patients without a readily apparent etiology present significant diagnostic and management challenges. We present a structured approach to diagnosis with consideration of common causes, including atherosclerosis and embolism, as well as uncommon causes, including medications and substances, vascular and anatomic abnormalities, systemic disorders, and thrombophilias. We highlight areas of management that have evolved within the past 5 years, including the use of dual-pathway inhibition in atherosclerotic disease, antithrombotic therapy selection in embolic stroke of undetermined source and left ventricular thrombus, the role of closure of patent foramen ovale for secondary stroke prevention, and the thrombotic potential of coronavirus disease 2019 infection and vaccination. We conclude with a representative case to illustrate the application of the diagnostic framework and discuss the importance of consideration of bleeding risk and patient preference in determining the appropriate management plan.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis Type of study: Case report / Diagnostic study / Etiology study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Female / Humans Language: English Journal: Hematology Am Soc Hematol Educ Program Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: Hematology.2021000235

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis Type of study: Case report / Diagnostic study / Etiology study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Female / Humans Language: English Journal: Hematology Am Soc Hematol Educ Program Journal subject: Hematology Year: 2021 Document Type: Article Affiliation country: Hematology.2021000235