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Clinical Features and Outcome of Stroke with COVID-19. COVID-19 Stroke Study Group (CSSG), India.
Bhatia, Rohit; Padma Srivastava, M V; Sylaja, P N; Komakula, Snigdha; Upadhyay, Ashish; Pardasani, Vibhor; Iype, Thomas; Parthasarathy, Rajsrinivas; Reddy, Rajshekhar; Kushwaha, Suman; Roy, Jayanta; Satish, P; Trikha, Anjan; Wig, Naveet; Dhar, Lalit; Vibha, Deepti; Vishnu, Venugopalan Y; Pandit, Awadh Kishore; Gupta, Anu; Elavarasi, A; Agarwal, Ayush; Gupta, Vipul; Singh, Rakesh K; Oza, Harsh; Halani, Hiral; Ramachandran, Dileep; George, Githin B; Panicker, Praveen; Suresh, M K; Kumaravelu, S; Khurana, Dheeraj; Rajendran, Srijithesh P; Pamidimukkala, Vijaya; Gupta, Salil; Pandian, Jeyaraj D; Chowdhury, Debashish; Rai, Nirendra K; Sharma, Arvind; Nambiar, Vivek K.
  • Bhatia R; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Padma Srivastava MV; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Sylaja PN; Department of Neurology, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
  • Komakula S; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Upadhyay A; Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
  • Pardasani V; Department of Neurology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
  • Iype T; Department of Neurology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India.
  • Parthasarathy R; Department of Neurology, Artemis Hospitals, Gurgaon, Haryana, India.
  • Reddy R; Department of Neurointervention Surgery, Artemis Hospitals, Gurgaon, Haryana, India.
  • Kushwaha S; Department of Neurology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India.
  • Roy J; Department of Neurology, Institute of Human Behaviour and Allied Sciences, Neurology, New Delhi, India.
  • Satish P; Department of Neurology, Institute of Neurosciences, Kolkata, West Bengal, India.
  • Trikha A; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Wig N; Department of Anaesthesia, All India Institute of Medical Sciences, New Delhi, India.
  • Dhar L; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Vibha D; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  • Vishnu VY; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Pandit AK; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Gupta A; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Elavarasi A; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Agarwal A; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Gupta V; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Singh RK; Department of Neurointervention Surgery, Artemis Hospitals, Gurgaon, Haryana, India.
  • Oza H; Department of Neurology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
  • Halani H; Department of Neurology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
  • Ramachandran D; Department of Neurology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India.
  • George GB; Department of Neurology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India.
  • Panicker P; Department of Neurology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India.
  • Suresh MK; Department of Neurology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India.
  • Kumaravelu S; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  • Khurana D; Department of Neurology, Ramesh Hospitals Guntur, Andhra Pradesh, India.
  • Rajendran SP; Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Pamidimukkala V; Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India.
  • Gupta S; Department of Neurology, Lalitha Super Specialty Hospital, Guntur, Andhra Pradesh, India.
  • Pandian JD; Department of Neurology, Command Hospital Air Force Bangalore, Bangalore, Karnataka, India.
  • Chowdhury D; Department of Neurology, Christian Medical College, Ludhiana, Punjab, India.
  • Rai NK; Department of Neurology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, Delhi, India.
  • Sharma A; Department of Neurology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
  • Nambiar VK; Department of Neurology, Zydus Hospital, Ahmedabad, Gujarat, India.
Ann Indian Acad Neurol ; 24(5): 668-685, 2021.
Article in English | MEDLINE | ID: covidwho-1566723
ABSTRACT
BACKGROUND AND

PURPOSE:

Occurrence of stroke has been reported among patients with COVID-19. The present study compares clinical features and outcomes of stroke patients with and without COVID-19.

METHODS:

The COVID-19 Stroke Study Group (CSSG) is a multicentric study in 18 sites across India to observe and compare the clinical characteristics of patients with stroke admitted during the current pandemic period and a similar epoch in 2019. The present study reports patients of stroke with and without COVID-19 (CoVS and non-CoVS, respectively) seen between February 2020 and July 2020. Demographic, clinical, treatment, and outcome details of patients were collected.

RESULTS:

The mean age and gender were comparable between the two groups. CoVS patients had higher stroke severity and extent of cerebral involvement on imaging. In-hospital complications and death were higher among CoVS patients (53.06% vs. 17.51%; P < 0.001) and (42.31% vs. 7.6%; P < 0.001), respectively. At 3 months, higher mortality was observed among CoVS patients (67.65% vs. 13.43%; P < 0.001) and good outcome (modified Rankin score [mRS] 0-2) was seen more often in non-CoVS patients (68.86% vs. 33.33%; P < 0.001). The presence of COVID-19 and baseline stroke severity were independent predictors of mortality.

CONCLUSIONS:

CoVS is associated with higher severity, poor outcome, and increased mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and baseline stroke severity are independent predictors of mortality.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Language: English Journal: Ann Indian Acad Neurol Year: 2021 Document Type: Article Affiliation country: Aian.AIAN_122_21

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Language: English Journal: Ann Indian Acad Neurol Year: 2021 Document Type: Article Affiliation country: Aian.AIAN_122_21