Clinical update on the use of mesenchymal stem cells in COVID-19
American Journal of Translational Research
; 13(11):12195-12205, 2021.
Article
in English
| EMBASE | ID: covidwho-1567695
ABSTRACT
The COVID-19 pandemic has evoked the scientific community to combine all efforts needed to find a cure for the disease. With the limited therapeutic effects of pharmacological therapies, attention has been drawn to alternative ones such as stem-cell based therapy particularly with mesenchymal stem cells (MSCs). Recently, a large number of clinical trials are ongoing to evaluate the safety and efficacy of MSCs in patients with COVID-19;however, only very few data are released. Thereby, we anxiously await the results of FDA-approved trials to provide more definitive data on the use of MSCs in COVID-19 patients, especially the critically ill. Herein, we shed light on the therapeutic agents that have been tested and used for the treatment of COVID-19 and provide an insight into MSC-based approaches for COVID-19 at both preclinical and clinical levels.
NCT03042143; NCT04252118; NCT04269525; NCT04276987; NCT04288102; NCT04299152; NCT04302519; NCT04313322; NCT04315987; NCT04333368; NCT04336254; NCT04345601; NCT04346368; NCT04348435; NCT04349631; NCT04352803; NCT04355728; NCT04361942; NCT04362189; NCT04366063; NCT04371393; NCT04371601; NCT04377334; NCT04382547; NCT04390139; NCT04390152; NCT04392778; NCT04397796; NCT04398303; NCT04400032; NCT04416139; NCT04428801; NCT04429763; NCT04437823; NCT04444271; NCT04445220; NCT04447833; NCT04452097; NCT04456361; NCT04457609; NCT04461925; NCT04466098; NCT04467047; NCT04490486; NCT04491240; NCT04492501; NCT04494386; NCT04522986; NCT04524962; NCT04527224; NCT04535856; NCT04537351; NCT04541680; NCT04565665; NCT04573270; NCT04602442; NCT04611256; NCT04629105; NCT04684602; NCT04713878; NCT04728698; NCT04753476; NCT04780685; NCT04798716; interleukin, 1beta; antiviral, activity; apoptosis; cell, differentiation; cell, therapy; chondrocyte; computer, assisted, tomography; coronavirus, disease, 2019; enzyme, linked, immunosorbent, assay; exosome; gene, therapy; genomic, instability; glycosylation; human; immunosuppressive, treatment; mesenchymal, stem, cell; osteocyte; oxidative, stress; regenerative, medicine; review; signal, transduction
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Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
English
Journal:
American Journal of Translational Research
Year:
2021
Document Type:
Article
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