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Association of COVID-19 mortality with COVID-19 vaccination rates in Rhineland-Palatinate (Germany) from calendar week 1 to 20 in the year 2021: a registry-based analysis.
Wollschläger, Daniel; Gianicolo, Emilio; Blettner, Maria; Hamann, Ruben; Herm-Stapelberg, Nils; Schoeps, Melissa.
  • Wollschläger D; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany. wollschlaeger@uni-mainz.de.
  • Gianicolo E; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.
  • Blettner M; Institute of Clinical Physiology of the Italian National Research Council (IFC-CNR), Lecce, Italy.
  • Hamann R; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.
  • Herm-Stapelberg N; Division of Vaccine Documentation, Cancer Registry Rhineland-Palatinate, Mainz, Germany.
  • Schoeps M; Division of Vaccine Documentation, Cancer Registry Rhineland-Palatinate, Mainz, Germany.
Eur J Epidemiol ; 36(12): 1231-1236, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1568382
ABSTRACT
Vaccination is among the measures implemented by authorities to control the spread of the COVID-19 pandemic. However, real-world evidence of population-level effects of vaccination campaigns against COVID-19 are required to confirm that positive results from clinical trials translate into positive public health outcomes. Since the age group 80 + years is most at risk for severe COVID-19 disease progression, this group was prioritized during vaccine rollout in Germany. Based on comprehensive vaccination data from the German federal state of Rhineland-Palatinate for calendar week 1-20 in the year 2021, we calculated sex- and age-specific vaccination coverage. Furthermore, we calculated the proportion of weekly COVID-19 fatalities and reported SARS-CoV-2 infections formed by each age group. Vaccination coverage in the age group 80 + years increased to a level of 80% (men) and 75% (women). Increasing vaccination coverage coincided with a reduction in the age group's proportion of COVID-19 fatalities. In multivariable logistic regression, vaccination coverage was associated both with a reduction in an age-group's proportion of COVID-19 fatalities [odds ratio (OR) per 5 percentage points = 0.89, 95% confidence interval (CI) = 0.82-0.96, p = 0.0013] and of reported SARS-CoV-2 infections (OR per 5 percentage points = 0.82, 95% CI 0.76-0.88, p < 0.0001). The results are consistent with a protective effect afforded by the vaccination campaign against severe COVID-19 disease in the oldest age group.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Eur J Epidemiol Journal subject: Epidemiology Year: 2021 Document Type: Article Affiliation country: S10654-021-00825-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Eur J Epidemiol Journal subject: Epidemiology Year: 2021 Document Type: Article Affiliation country: S10654-021-00825-6