Antigenic drift: Understanding COVID-19.

Yewdell, Jonathan W

Yewdell, Jonathan W.

Yewdell JW; Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA. Electronic address: jyewdell@nih.gov.

Immunity ; 54(12): 2681-2687, 2021 12 14.

Article in English | MEDLINE | ID: covidwho-1568762

ABSTRACT

ABSTRACT

Antigenic drift refers to the evolutionary accumulation of amino acid substitutions in viral proteins selected by host adaptive immune systems as the virus circulates in a population. Antigenic drift can substantially limit the duration of immunity conferred by infection and vaccination. Here, I explain the factors contributing to the rapid antigenic drift of the SARS-CoV-2 spike protein and receptor proteins of other viruses and discuss the implications for SARS-CoV-2 evolution and immunity.

Subject(s)

COVID-19/immunology; Mutation/genetics; SARS-CoV-2/physiology; Adaptive Immunity; Animals; Antigenic Drift and Shift; Biological Evolution; Host-Pathogen Interactions; Humans; Spike Glycoprotein, Coronavirus/immunology; Vaccination

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Mutation Topics: Vaccines Limits: Animals / Humans Language: English Journal: Immunity Journal subject: Allergy and Immunology Year: 2021 Document Type: Article

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