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Endothelial injury in COVID-19 and septic patients.
Hokama, Larissa Tami; Veiga, Alicia Dudy Müller; Menezes, Maria Clara Saad; Sardinha Pinto, Agnes Araujo; de Lima, Thais Martins; Ariga, Suely Kunimi Kubo; Barbeiro, Hermes Vieira; Barbeiro, Denise Frediani; de Lucena Moreira, Claudia; Stanzani, Gabriela; Brandao, Rodrigo Antonio; Marchini, Julio Flavio; Alencar, Julio Cesar; Marino, Lucas Oliveira; Gomez, Luz Marina; Souza, Heraldo P.
  • Hokama LT; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. Electronic address: larissa.tami@fm.usp.br.
  • Veiga ADM; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Menezes MCS; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Sardinha Pinto AA; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • de Lima TM; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Ariga SKK; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Barbeiro HV; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Barbeiro DF; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • de Lucena Moreira C; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Stanzani G; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Brandao RA; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Marchini JF; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Alencar JC; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Marino LO; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Gomez LM; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Souza HP; Emergency Medicine Department, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Microvasc Res ; 140: 104303, 2022 03.
Article in English | MEDLINE | ID: covidwho-1568955
ABSTRACT
Systemic inflammatory response, as observed in sepsis and severe COVID-19, may lead to endothelial damage. Therefore, we aim to compare the extent of endothelial injury and its relationship to inflammation in both diseases. We included patients diagnosed with sepsis (SEPSIS group, n = 21), mild COVID-19 (MILD group, n = 31), and severe COVID-19 (SEVERE group, n = 24). Clinical and routine laboratory data were obtained, circulating cytokines (INF-γ, TNF-α, and IL-10) and endothelial injury markers (E-Selectin, Tissue Factor (TF) and von Willebrand factor (vWF)) were measured. Compared to the SEPSIS group, patients with severe COVID-19 present similar clinical and laboratory data, except for lower circulating IL-10 and E-Selectin levels. Compared to the MILD group, patients in the SEVERE group showed higher levels of TNF-α, IL-10, and TF. There was no clear relationship between cytokines and endothelial injury markers among the three studied groups; however, in SEVERE COVID-19 patients, there is a positive relationship between INF-γ with TF and a negative relationship between IL-10 and vWF. In conclusion, COVID-19 and septic patients have a similar pattern of cytokines and endothelial dysfunction markers. These findings highlight the importance of endothelium dysfunction in COVID-19 and suggest that endothelium should be better evaluated as a therapeutic target for the disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / Systemic Inflammatory Response Syndrome / Sepsis / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Microvasc Res Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / Systemic Inflammatory Response Syndrome / Sepsis / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Microvasc Res Year: 2022 Document Type: Article