Your browser doesn't support javascript.
Towards a population-based threshold of protection for COVID-19 vaccines.
Goldblatt, David; Fiore-Gartland, Andrew; Johnson, Marina; Hunt, Adam; Bengt, Christopher; Zavadska, Dace; Snipe, Hilda Darta; Brown, Jeremy S; Workman, Lesley; Zar, Heather J; Montefiori, David; Shen, Xiaoying; Dull, Peter; Plotkin, Stanley; Siber, George; Ambrosino, Donna.
  • Goldblatt D; Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1 EH, UK; Great Ormond Street Children's Hospital NHS Foundation Trust, Great Ormond Street, London WC1N 3JH, UK. Electronic address: d.goldblatt@ucl.ac.uk.
  • Fiore-Gartland A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Johnson M; Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1 EH, UK.
  • Hunt A; Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1 EH, UK.
  • Bengt C; Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1 EH, UK.
  • Zavadska D; Children's Clinical University Hospital, Vienibas gatve 45, Riga LV-1004, Latvia.
  • Snipe HD; Children's Clinical University Hospital, Vienibas gatve 45, Riga LV-1004, Latvia.
  • Brown JS; UCL Respiratory, Division of Medicine, University College London, London WC1E 6JF, UK.
  • Workman L; Dept of Paediatrics & Child Health, Red Cross Children's Hospital, and SA-MRC Unit on Child & Adolescent Health, University of Cape Town, South Africa.
  • Zar HJ; Dept of Paediatrics & Child Health, Red Cross Children's Hospital, and SA-MRC Unit on Child & Adolescent Health, University of Cape Town, South Africa.
  • Montefiori D; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Shen X; Department of Surgery, Duke University Medical Center, Durham, NC, USA.
  • Dull P; Vaccine Development and Surveillance, Bill & Melinda Gates Foundation, Seattle, WA, USA.
  • Plotkin S; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Siber G; Independent Advisor, New York, NY, USA.
  • Ambrosino D; Independent Advisor, Stuart, FL, USA.
Vaccine ; 40(2): 306-315, 2022 01 21.
Article in English | MEDLINE | ID: covidwho-1569121
ABSTRACT
Correlates of protection for COVID-19 vaccines are urgently needed to license additional vaccines. We measured immune responses to four COVID-19 vaccines of proven efficacy using a single serological platform. IgG anti-Spike antibodies were highly correlated with ID50 neutralization in a validated pseudoviral assay and correlated significantly with efficacies for protection against infection with wild-type, alpha and delta variant SARS-CoV-2 virus. The protective threshold for each vaccine was calculated for IgG anti-Spike antibody. The mean protective threshold for all vaccine studies for WT virus was 154 BAU/ml (95 %CI 42-559), and for studies with antibody distributions that enabled precise estimation of thresholds (i.e. leaving out 2-dose mRNA regimens) was 60 BAU/ml (95 %CI 35-102). We propose that the proportion of individuals with responses above the appropriate protective threshold together with the geometric mean concentration can be used in comparative non-inferiority studies with licensed vaccines to ensure that new vaccines will be efficacious.
Subject(s)
Keywords
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Vaccine Year: 2022 Document Type: Article

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Vaccine Year: 2022 Document Type: Article