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Evolution of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroprevalence among employees of a US academic children's hospital during coronavirus disease 2019 (COVID-19) pandemic.
Fisher, Brian T; Sharova, Anna; Boge, Craig L K; Gouma, Sigrid; Kamrin, Audrey; Blumenstock, Jesse; Shuster, Sydney; Gianchetti, Lauren; Collins, Danielle; Akaho, Elikplim; Weirick, Madison E; McAllister, Christopher M; Bolton, Marcus J; Arevalo, Claudia P; Goodwin, Eileen C; Anderson, Elizabeth M; Christensen, Shannon R; Balamuth, Fran; John, Audrey R Odom; Li, Yun; Coffin, Susan; Gerber, Jeffrey S; Hensley, Scott E.
  • Fisher BT; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Sharova A; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Boge CLK; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Gouma S; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Kamrin A; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Blumenstock J; Center for Human Phenomic Science, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Shuster S; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Gianchetti L; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Collins D; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Akaho E; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Weirick ME; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • McAllister CM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Bolton MJ; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Arevalo CP; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Goodwin EC; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Anderson EM; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Christensen SR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Balamuth F; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • John ARO; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Li Y; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Coffin S; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Gerber JS; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Hensley SE; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Infect Control Hosp Epidemiol ; : 1-9, 2021 Dec 02.
Article in English | MEDLINE | ID: covidwho-1569174
ABSTRACT

OBJECTIVE:

To describe the cumulative seroprevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) antibodies during the coronavirus disease 2019 (COVID-19) pandemic among employees of a large pediatric healthcare system. DESIGN, SETTING, AND

PARTICIPANTS:

Prospective observational cohort study open to adult employees at the Children's Hospital of Philadelphia, conducted April 20-December 17, 2020.

METHODS:

Employees were recruited starting with high-risk exposure groups, utilizing e-mails, flyers, and announcements at virtual town hall meetings. At baseline, 1 month, 2 months, and 6 months, participants reported occupational and community exposures and gave a blood sample for SARS-CoV-2 antibody measurement by enzyme-linked immunosorbent assays (ELISAs). A post hoc Cox proportional hazards regression model was performed to identify factors associated with increased risk for seropositivity.

RESULTS:

In total, 1,740 employees were enrolled. At 6 months, the cumulative seroprevalence was 5.3%, which was below estimated community point seroprevalence. Seroprevalence was 5.8% among employees who provided direct care and was 3.4% among employees who did not perform direct patient care. Most participants who were seropositive at baseline remained positive at follow-up assessments. In a post hoc analysis, direct patient care (hazard ratio [HR], 1.95; 95% confidence interval [CI], 1.03-3.68), Black race (HR, 2.70; 95% CI, 1.24-5.87), and exposure to a confirmed case in a nonhealthcare setting (HR, 4.32; 95% CI, 2.71-6.88) were associated with statistically significant increased risk for seropositivity.

CONCLUSIONS:

Employee SARS-CoV-2 seroprevalence rates remained below the point-prevalence rates of the surrounding community. Provision of direct patient care, Black race, and exposure to a confirmed case in a nonhealthcare setting conferred increased risk. These data can inform occupational protection measures to maximize protection of employees within the workplace during future COVID-19 waves or other epidemics.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Language: English Journal: Infect Control Hosp Epidemiol Journal subject: Communicable Diseases / Nursing / Epidemiology / Hospitals Year: 2021 Document Type: Article Affiliation country: Ice.2021.487

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Randomized controlled trials / Risk factors Language: English Journal: Infect Control Hosp Epidemiol Journal subject: Communicable Diseases / Nursing / Epidemiology / Hospitals Year: 2021 Document Type: Article Affiliation country: Ice.2021.487