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Impact of vaccination on the spread of SARS-CoV-2 infection in north-east Italy nursing homes. A propensity score and risk analysis.
Pierobon, Silvia; Braggion, Marco; Fedeli, Ugo; Nordio, Maurizio; Basso, Cristina; Zorzi, Manuel.
  • Pierobon S; Epidemiological Department, Azienda Zero, Veneto Region, Padova 35132, Italy.
  • Braggion M; Epidemiological Department, Azienda Zero, Veneto Region, Padova 35132, Italy.
  • Fedeli U; Epidemiological Department, Azienda Zero, Veneto Region, Padova 35132, Italy.
  • Nordio M; Unit of Nephrology, General Hospital, Treviso 31100, Italy.
  • Basso C; Epidemiological Department, Azienda Zero, Veneto Region, Padova 35132, Italy.
  • Zorzi M; Epidemiological Department, Azienda Zero, Veneto Region, Padova 35132, Italy.
Age Ageing ; 51(1)2022 01 06.
Article in English | MEDLINE | ID: covidwho-1569566
ABSTRACT

BACKGROUND:

In the Veneto Region, 421,000 coronavirus 2019 disease (COVID-19) cases and 11,000 deaths have been reported since 21 February 2020. The pandemic spread particularly in nursing homes (NH).

OBJECTIVE:

This study estimated the impact of SARS-CoV-2 infection among NH residents, focusing on the risk of hospitalisation and death due to COVID-19 compared with the general older population. It also provided evidence of risk changes over time.

METHODS:

Older people, resident in Veneto, were enrolled from the regional registry of the population. We collected also information about demographic characteristics, chronic diseases, COVID-19 positivity, NH institutionalization, hospitalisation and date of death. Patients were assigned to NH or non-NH residents groups through a propensity score 11 matching. The follow-up period was defined as 21 February 2020 - 3 May 2021 and then divided into three waves. Risk ratios (RRs) and 95% confidence interval were estimated by using Poisson models with robust estimation of variance.

RESULTS:

NH residents showed a higher risk of COVID-19 infection (RR = 6.28; 6.03-6.54), hospitalisation for COVID-19 (RR = 2.20; 2.05-2.36) and death with COVID-19 (RR = 6.07; 5.58-6.61).

CONCLUSION:

NH residents shared common spaces with other patients and healthcare professionals and were more exposed to infections. Nonetheless, in Italy from late December 2020 to May 2021, 95% of NH residents and their healthcare professionals received at least one vaccine dose and RRs for all outcomes decreased in NH.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Aged / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ageing

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Aged / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ageing