Predictors and outcomes of respiratory failure among lung transplant patients with COVID-19.
Clin Transplant
; 36(3): e14540, 2022 03.
Article
in English
| MEDLINE | ID: covidwho-1570566
ABSTRACT
BACKGROUND:
There is limited data on the predictors and outcomes of new or worsening respiratory failure among lung transplant (LT) patients with Coronavirus disease 2019 (COVID-19).METHODS:
We included all the LT patients diagnosed with COVID-19 during a 1-year period (March 2020 to February 2021; n = 54; median age 60, 20-73 years; MF 3717). Development of new or worsening respiratory failure (ARF) was the primary outcome variable.RESULTS:
The overall incidence of ARF was 48.1% (n = 26). More than 20% of patients (n = 11) needed intubation and mechanical ventilation. Body mass index > 25 Kg/m2 (adjusted OR 5.7, .99-32.93; P = .05) and peak D-dimer levels > .95 mcg/ml (adjusted OR 24.99, 1.77-353.8; P = .017) were independently associated with ARF while anticoagulation use prior to COVID-19 was protective (adjusted OR .024, .001-.55; P = .02). Majority patients survived the acute illness (85.2%). Pre-infection chronic lung allograft dysfunction (CLAD) was an independent predictor of mortality (adjusted HR 5.03, 1.14-22.25; P = .033).CONCLUSIONS:
COVID-19 is associated with significant morbidity and mortality among LT patients. Patients on chronic anticoagulation seem to enjoy favorable outcomes, while higher BMI and peak D-dimer levels are associated with development of ARF. Pre-infection CLAD is associated with an increased risk of death from COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Insufficiency
/
Lung Transplantation
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clin Transplant
Journal subject:
Transplantation
Year:
2022
Document Type:
Article
Affiliation country:
CTR.14540
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