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Are Patients with Inflammatory Bowel Disease at Increased Risk for Covid-19 Infection?
Monteleone, Giovanni; Ardizzone, Sandro.
  • Monteleone G; Department of Systems Medicine, University of Rome 'TOR VERGATA', Rome, Italy.
  • Ardizzone S; Gastrointestinal Unit, ASST-Fatebenefratelli Sacco - Department of Biochemical and Clinical Sciences 'L. Sacco', University of Milan, Italy.
J Crohns Colitis ; 14(9): 1334-1336, 2020 Sep 16.
Article in English | MEDLINE | ID: covidwho-15707
ABSTRACT
Crohn's disease [CD] and ulcerative colitis [UC], the main inflammatory bowel diseases [IBD] in humans, are chronic, immune-inflammatory diseases, the pathogenesis of which suggests a complex interaction between environmental factors and genetic susceptibility. These disabling conditions affect millions of individuals and, together with the drugs used to treat them, can put patients at risk of developing complications and other conditions. This is particularly relevant today, as coronavirus disease [Covid-19] has rapidly spread from China to countries where IBD are more prevalent, and there is convincing evidence that Covid-19-mediated morbidity and mortality are higher in subjects with comorbidities. The primary objectives of this Viewpoint are to provide a focused overview of the factors and mechanisms by which the novel severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infects cells and to illustrate the link between such determinants and intestinal inflammation. We also provide clues about the reasons why the overall IBD population might have no increased risk of developing SARS-CoV-2 infection and highlight the potential of cytokine blockers, used to treat IBD patients, to prevent Covid-driven pneumonia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Colitis, Ulcerative / Crohn Disease / Coronavirus Infections / Pandemics Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J Crohns Colitis Journal subject: Gastroenterology Year: 2020 Document Type: Article Affiliation country: Ecco-jcc

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Colitis, Ulcerative / Crohn Disease / Coronavirus Infections / Pandemics Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J Crohns Colitis Journal subject: Gastroenterology Year: 2020 Document Type: Article Affiliation country: Ecco-jcc