Your browser doesn't support javascript.
Effect of COVID-19 on Kawasaki Disease: Decrease Age of Onset and Increase Skin Manifestation.
Esmaeilzadeh, Hossein; Mortazavi, Negar; Salehi, Alireza; Fatemian, Hossein; Dehghani, Seyed Mohsen; Vali, Mohebat; Vardanjani, Hossein Molavi.
  • Esmaeilzadeh H; Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. esmailzadeh_ho@yahoo.com.
  • Mortazavi N; Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. esmailzadeh_ho@yahoo.com.
  • Salehi A; MD/MPH Program, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. esmailzadeh_ho@yahoo.com.
  • Fatemian H; Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. mortazavi_ne@yahoo.com.
  • Dehghani SM; MD/MPH Program, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Vali M; Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Vardanjani HM; Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Pediatr ; 21(1): 571, 2021 12 13.
Article in English | MEDLINE | ID: covidwho-1571749
ABSTRACT

BACKGROUND:

Kawasaki Disease (KD) is the most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children. We performed this study to assess the association between KD and COVID-19. We evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period time in 2019 (group two). We also compared the same data in COVID-19 positive and COVID-19 negative KD patients in 2020 pandemic period in Shiraz Namazi referral hospital at southwest of Iran.

RESULTS:

Thirty-two patients in group one compared with 44 patients in group two. Sixty-eight percent of group one KD patients were positive for COVID-19 during the pandemic period. KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value = 0.044). There was no difference in the demographic, clinical, laboratory, and echocardiographic features of the patients during and before the COVID-19 pandemic (p-value > 0.05). Moreover, Comparing COVID-19 positive and negative the incidence of rash was higher within COVID-19 positive cases (p < 0.05), and coronary artery abnormalities were more prevalent in COVID-19 negative cases (p < 0.05).

CONCLUSION:

Admission rate of KD was almost similar during the COVID-19 pandemic but 68% of KD admitted patient were COVID-19 positive. Age of onset for KD during the COVID-19 pandemic was lower and skin manifestation was higher than the same period time in last year.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mucocutaneous Lymph Node Syndrome Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Child / Child, preschool / Humans Language: English Journal: BMC Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: S12887-021-03060-w

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mucocutaneous Lymph Node Syndrome Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Child / Child, preschool / Humans Language: English Journal: BMC Pediatr Journal subject: Pediatrics Year: 2021 Document Type: Article Affiliation country: S12887-021-03060-w