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Delirium and other neuropsychiatric manifestations of COVID-19 infection in people with preexisting psychiatric disorders: a systematic review.
van Reekum, Emma A; Rosic, Tea; Sergeant, Anjali; Sanger, Nitika; Rodrigues, Myanca; Rebinsky, Reid; Panesar, Balpreet; Deck, Eve; Kim, Nayeon; Woo, Julia; D'Elia, Alessia; Hillmer, Alannah; Dufort, Alexander; Sanger, Stephanie; Thabane, Lehana; Mbuagbaw, Lawrence; Samaan, Zainab.
  • van Reekum EA; Department of Psychiatry and Behavioural Neurosciences, Clinician Investigator Program, McMaster University, Hamilton, Canada.
  • Rosic T; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
  • Sergeant A; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
  • Sanger N; Medical Science Graduate Program, McMaster University, Hamilton, Canada.
  • Rodrigues M; Health Research Methodology Graduate Program, McMaster University, Hamilton, Canada.
  • Rebinsky R; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
  • Panesar B; Neuroscience Graduate Program, McMaster University, Hamilton, Canada.
  • Deck E; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
  • Kim N; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
  • Woo J; Department of Psychiatry and Behavioural Neurosciences, Clinician Investigator Program, McMaster University, Hamilton, Canada.
  • D'Elia A; Neuroscience Graduate Program, McMaster University, Hamilton, Canada.
  • Hillmer A; Neuroscience Graduate Program, McMaster University, Hamilton, Canada.
  • Dufort A; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Canada.
  • Sanger S; Health Sciences Library, McMaster University, Hamilton, Canada.
  • Thabane L; Department of Health Research, Evidence and Impact, McMaster University, Hamilton, Canada.
  • Mbuagbaw L; St. Joseph's Healthcare Hamilton, 100 West 5th Street, Hamilton, ON, L8N 3K7, Canada.
  • Samaan Z; Department of Health Research, Evidence and Impact, McMaster University, Hamilton, Canada.
J Med Case Rep ; 15(1): 586, 2021 Dec 13.
Article in English | MEDLINE | ID: covidwho-1571926
ABSTRACT

BACKGROUND:

Psychiatric disorders increase risk of neuropsychiatric disease and poor outcomes, yet little is known about the neuropsychiatric manifestations of COVID-19 in the psychiatric population. The primary objective is to synthesize neuropsychiatric outcomes of COVID-19 in people with preexisting psychiatric disorders.

METHODS:

Data were collected during an ongoing review of the impact of pandemics on people with existing psychiatric disorders. All study designs and gray literature were included. Medline, PsychInfo, CINAHL, EMBASE, and MedRx were searched from inception to September 1 2020. Risk of bias was assessed using a published tool that can accommodate all study types. Two independent authors screened the studies and extracted data. Data were narratively synthesized, as there were insufficient data to meta-analyze. Evidence was appraised according to GRADE.

RESULTS:

Four case reports were included, comprising 13 participants from three countries. Many large-sample, relevant papers were omitted for not reporting psychiatric history, despite reporting other comorbidities. Included participants (n = 13) were hospitalized with COVID-19 and appeared to meet criteria for delirium. Myoclonus, rigidity, and alogia were also reported. The most commonly reported preexisting psychiatric diagnoses were mood disorders, schizophrenia, and alcohol use disorder.

CONCLUSIONS:

People with preexisting psychiatric disorders may experience delirium, rigidity, myoclonus, and alogia during COVID-19 infection; although higher quality and longitudinal data are needed to better understand these phenomena. Relevant COVID-19 literature does not always report psychiatric history, despite heightened neuropsychiatric vulnerability within this population. TRIAL REGISTRATION  PROSPERO (CRD42020179611).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Delirium / COVID-19 Type of study: Randomized controlled trials / Reviews / Systematic review Limits: Humans Language: English Journal: J Med Case Rep Year: 2021 Document Type: Article Affiliation country: S13256-021-03140-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Delirium / COVID-19 Type of study: Randomized controlled trials / Reviews / Systematic review Limits: Humans Language: English Journal: J Med Case Rep Year: 2021 Document Type: Article Affiliation country: S13256-021-03140-6