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Spontaneous Muscle Hematoma in Japanese Patients with Severe COVID-19 Treated with Unfractionated Heparin: Two Case Reports.
Ito, Yu; Awano, Nobuyasu; Uchiyama, Fumiya; Inomata, Minoru; Kuse, Naoyuki; Tone, Mari; Takada, Kohei; Fujimoto, Kazushi; Muto, Yutaka; Sagisaka, Shogo; Maki, Kenro; Yamashita, Ryuta; Harada, Akinori; Nishimura, Jun-Ichi; Hayashi, Munehiro; Izumo, Takehiro.
  • Ito Y; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
  • Awano N; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
  • Uchiyama F; Department of Interventional Radiology, Japanese Red Cross Medical Center, Japan.
  • Inomata M; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
  • Kuse N; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
  • Tone M; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
  • Takada K; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
  • Fujimoto K; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
  • Muto Y; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
  • Sagisaka S; Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, Japan.
  • Maki K; Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, Japan.
  • Yamashita R; Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, Japan.
  • Harada A; Department of Interventional Radiology, Japanese Red Cross Medical Center, Japan.
  • Nishimura JI; Department of Interventional Radiology, Japanese Red Cross Medical Center, Japan.
  • Hayashi M; Department of Emergency and Critical Care Medicine, Japanese Red Cross Medical Center, Japan.
  • Izumo T; Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan.
Intern Med ; 60(21): 3503-3506, 2021 Nov 01.
Article in English | MEDLINE | ID: covidwho-1572222
ABSTRACT
In hospitalized coronavirus disease 2019 (COVID-19) patients, anticoagulation therapy is administered to prevent thrombosis. However, anticoagulation sometimes causes bleeding complications. We herein report two Japanese cases of severe COVID-19 in which spontaneous muscle hematomas (SMH) developed under therapeutic anticoagulation with unfractionated heparin. Although the activated partial prothrombin time was within the optimal range, contrast-enhanced computed tomography (CECT) revealed SMH in the bilateral iliopsoas muscles in both cases, which required emergent transcatheter embolization. Close monitoring of the coagulation system and the early diagnosis of bleeding complications through CECT are needed in severe COVID-19 patients treated with anticoagulants.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heparin / COVID-19 Type of study: Case report Limits: Humans Country/Region as subject: Asia Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Internalmedicine.7422-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heparin / COVID-19 Type of study: Case report Limits: Humans Country/Region as subject: Asia Language: English Journal: Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Internalmedicine.7422-21