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Neck Circumference Predicts Mortality in Hospitalized COVID-19 Patients.
Di Bella, Stefano; Zerbato, Verena; Sanson, Gianfranco; Roman-Pognuz, Erik; De Cristofaro, Paolo; Palermo, Andrea; Valentini, Michael; Gobbo, Ylenia; Jaracz, Anna Wladyslawa; Bozic Hrzica, Elizabeta; Bresani-Salvi, Cristiane Campello; Galindo, Alexandre Bezerra; Crovella, Sergio; Luzzati, Roberto.
  • Di Bella S; Clinical Department of Medical, Surgical and Health Sciences, Trieste University, 34149 Trieste, Italy.
  • Zerbato V; Infectious Diseases Unit, Trieste University Hospital (ASUGI), 34125 Trieste, Italy.
  • Sanson G; Clinical Department of Medical, Surgical and Health Sciences, Trieste University, 34149 Trieste, Italy.
  • Roman-Pognuz E; Clinical Department of Medical, Surgical and Health Sciences, Trieste University, 34149 Trieste, Italy.
  • De Cristofaro P; Clinical Endocrinology and Metabolism Outpatient Clinic, 64021 Giulianova, Italy.
  • Palermo A; Unit of Endocrinology and Diabetes, University Campus Bio-Medico, 00128 Rome, Italy.
  • Valentini M; Infectious Diseases Unit, Trieste University Hospital (ASUGI), 34125 Trieste, Italy.
  • Gobbo Y; Infectious Diseases Unit, Trieste University Hospital (ASUGI), 34125 Trieste, Italy.
  • Jaracz AW; Infectious Diseases Unit, Trieste University Hospital (ASUGI), 34125 Trieste, Italy.
  • Bozic Hrzica E; Infectious Diseases Unit, Trieste University Hospital (ASUGI), 34125 Trieste, Italy.
  • Bresani-Salvi CC; Laboratory of Virology and Experimental Therapy, Oswaldo Cruz Foundation, Ministry of Health, Recife 50070-902, Brazil.
  • Galindo AB; School of Health and Life Science, Catholic University of Pernambuco, Recife 50070-902, Brazil.
  • Crovella S; Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha 2713, Qatar.
  • Luzzati R; Clinical Department of Medical, Surgical and Health Sciences, Trieste University, 34149 Trieste, Italy.
Infect Dis Rep ; 13(4): 1053-1060, 2021 Dec 10.
Article in English | MEDLINE | ID: covidwho-1572438
ABSTRACT
We aimed to determine whether neck circumference predicts mortality among hospitalized COVID-19 patients with respiratory failure. We performed a prospective multicenter (Italy and Brasil) study carried out from March to December 2020 on 440 hospitalized COVID-19 patients with respiratory failure. Baseline neck circumference was measured. The study outcome was 30- and 60-days mortality. Female and male participants were classified as "large neck" when exceeding fourth-quartile. Patients had a median age of 65 years (IQR 54-76), 68% were male. One-quarter of patients presented with grade-1 or higher obesity. The median neck circumference was 40 cm (IQR 38-43) 38 cm (IQR 36-40) for female and 41 cm (IQR 39-44) for male subjects. "Large neck" patients had a significantly higher prevalence of hypertension (63 vs. 48%), diabetes (33 vs. 19%), obesity (26 vs. 14%), and elevated C-reactive protein (CRP) (98 vs. 88%). The cumulative mortality rate was 13.1% (n = 52) and 15.9% (n = 63) at 30 and 60 days, respectively. After adjusting for age, BMI, relevant comorbidities, and high C-reactive protein to albumin ratio, "large neck" patients showed a significantly increased risk of death at 30- (adjusted HR 2.50; 95% CI 1.18-5.29; p = 0.017) and 60-days (adjusted HR 2.26; 95% CI 1.14-4.46; p = 0.019). Neck circumference is easy to collect and provides additional prognostic information to BMI. Among hospitalized COVID-19 patients with respiratory failure, those with large neck phenotype had a more than double risk of death at 30 and 60 days.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Infect Dis Rep Year: 2021 Document Type: Article Affiliation country: Idr13040096

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Infect Dis Rep Year: 2021 Document Type: Article Affiliation country: Idr13040096