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SARS-CoV-2 Infection in Patients on Dialysis: Incidence and Outcomes in the Lazio Region, Italy.
Marino, Claudia; Angelici, Laura; Pistolesi, Valentina; Morabito, Santo; Di Napoli, Anteo; Calandrini, Enrico; Cascini, Silvia; Bargagli, Anna Maria; Petrosillo, Nicola; Agabiti, Nera; Davoli, Marina.
  • Marino C; Department of Epidemiology of the Regional Health Service-Lazio, Via Cristoforo Colombo, 112, 00147 Rome, Italy.
  • Angelici L; Department of Epidemiology of the Regional Health Service-Lazio, Via Cristoforo Colombo, 112, 00147 Rome, Italy.
  • Pistolesi V; Department of Internal Medicine and Medical Specialties, Hemodialysis Unit, Umberto I, Policlinico di Roma, "Sapienza" University School of Medicine, 00161 Rome, Italy.
  • Morabito S; Department of Internal Medicine and Medical Specialties, Hemodialysis Unit, Umberto I, Policlinico di Roma, "Sapienza" University School of Medicine, 00161 Rome, Italy.
  • Di Napoli A; National Institute for Health, Migration and Poverty, 00153 Rome, Italy.
  • Calandrini E; Department of Epidemiology of the Regional Health Service-Lazio, Via Cristoforo Colombo, 112, 00147 Rome, Italy.
  • Cascini S; Department of Epidemiology of the Regional Health Service-Lazio, Via Cristoforo Colombo, 112, 00147 Rome, Italy.
  • Bargagli AM; Department of Epidemiology of the Regional Health Service-Lazio, Via Cristoforo Colombo, 112, 00147 Rome, Italy.
  • Petrosillo N; Infectious Disease and Infection Control Unit, Campus Bio-Medico, Medicine University Hospital, 00128 Rome, Italy.
  • Agabiti N; Department of Epidemiology of the Regional Health Service-Lazio, Via Cristoforo Colombo, 112, 00147 Rome, Italy.
  • Davoli M; Department of Epidemiology of the Regional Health Service-Lazio, Via Cristoforo Colombo, 112, 00147 Rome, Italy.
J Clin Med ; 10(24)2021 Dec 13.
Article in English | MEDLINE | ID: covidwho-1572524
ABSTRACT
Patients with end-stage kidney disease represent a frail population and might be at higher risk of SARS-CoV-2 infection. The Lazio Regional Dialysis and Transplant Registry collected information on dialysis patients with a positive swab. The study investigated incidence of SARS-CoV-2 infection, mortality and their potential associated factors in patients undergoing maintenance hemodialysis (MHD) in the Lazio region.

Method:

The occurrence of infection was assessed among MHD patients included in the RRDTL from 1 March to 30 November 2020. The adjusted cumulative incidence of infection and mortality risk within 30 days of infection onset were estimated. Logistic and Cox regression models were applied to identify factors associated with infection and mortality, respectively.

Results:

The MHD cohort counted 4942 patients; 256 (5.2%) had COVID-19. The adjusted cumulative incidence was 5.1%. Factors associated with infection included being born abroad, educational level, cystic renal disease/familial nephropathy, vascular disease and being treated in a dialysis center located in Local Health Authority (LHA) Rome 2. Among infected patients, 59 (23.0%) died within 30 days; the adjusted mortality risk was 21.0%. Factors associated with 30-day mortality included age, malnutrition and fever at the time of swab.

Conclusions:

Factors associated with infection seem to reflect socioeconomic conditions. Factors associated with mortality, in addition to age, are related to clinical characteristics and symptoms at the time of swab.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Incidence study / Prognostic study / Risk factors Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10245818

Full text: Available Collection: International databases Database: MEDLINE Type of study: Incidence study / Prognostic study / Risk factors Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10245818