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Iron Related Biomarkers Predict Disease Severity in a Cohort of Portuguese Adult Patients during COVID-19 Acute Infection.
Moreira, Ana C; Teles, Maria Jose; Silva, Tânia; Bento, Clara M; Alves, Inês Simões; Pereira, Luisa; Guimarães, João Tiago; Porto, Graça; Oliveira, Pedro; Gomes, Maria Salomé.
  • Moreira AC; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
  • Teles MJ; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.
  • Silva T; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
  • Bento CM; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
  • Alves IS; CHUSJ-Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal.
  • Pereira L; ISPUP-EPIUnit-Instituto de Saúde Pública da Universidade do Porto, 4050-091 Porto, Portugal.
  • Guimarães JT; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
  • Porto G; IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.
  • Oliveira P; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal.
  • Gomes MS; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
Viruses ; 13(12)2021 12 10.
Article in English | MEDLINE | ID: covidwho-1572659
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ABSTRACT
Large variability in COVID-19 clinical progression urges the need to find the most relevant biomarkers to predict patients' outcomes. We evaluated iron metabolism and immune response in 303 patients admitted to the main hospital of the northern region of Portugal with variable clinical pictures, from September to November 2020. One hundred and twenty-seven tested positive for SARS-CoV-2 and 176 tested negative. Iron-related laboratory parameters and cytokines were determined in blood samples collected soon after admission. Demographic data, comorbidities and clinical outcomes were recorded. Patients were assigned into five groups according to severity. Serum iron and transferrin levels at admission were lower in COVID-19-positive than in COVID-19-negative patients. The levels of interleukin (IL)-6 and monocyte chemoattractant protein 1 (MCP-1) were increased in COVID-19-positive patients. The lowest serum iron and transferrin levels at diagnosis were associated with the worst outcomes. Iron levels negatively correlated with IL-6 and higher levels of this cytokine were associated with a worse prognosis. Serum ferritin levels at diagnosis were higher in COVID-19-positive than in COVID-19-negative patients. Serum iron is the simplest laboratory test to be implemented as a predictor of disease progression in COVID-19-positive patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Biomarkers / COVID-19 / Iron Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13122482

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Biomarkers / COVID-19 / Iron Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2021 Document Type: Article Affiliation country: V13122482