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High-Fat High-Sugar Diet-Induced Changes in the Lipid Metabolism Are Associated with Mildly Increased COVID-19 Severity and Delayed Recovery in the Syrian Hamster.
Port, Julia R; Adney, Danielle R; Schwarz, Benjamin; Schulz, Jonathan E; Sturdevant, Daniel E; Smith, Brian J; Avanzato, Victoria A; Holbrook, Myndi G; Purushotham, Jyothi N; Stromberg, Kaitlin A; Leighton, Ian; Bosio, Catharine M; Shaia, Carl; Munster, Vincent J.
  • Port JR; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Adney DR; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Schwarz B; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Schulz JE; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Sturdevant DE; Genomics Unit, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Smith BJ; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institutes of Health, Hamilton, MT 59840, USA.
  • Avanzato VA; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Holbrook MG; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Purushotham JN; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Stromberg KA; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Leighton I; The Jenner Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7BN, UK.
  • Bosio CM; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Shaia C; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • Munster VJ; Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Viruses ; 13(12)2021 12 14.
Article in English | MEDLINE | ID: covidwho-1572667
ABSTRACT
Pre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we demonstrate the detrimental impact of a continuous high-fat high-sugar diet on COVID-19 outcome. We observed increased weight loss and lung pathology, such as exudate, vasculitis, hemorrhage, fibrin, and edema, delayed viral clearance and functional lung recovery, and prolonged viral shedding. This was accompanied by an altered, but not significantly different, systemic IL-10 and IL-6 profile, as well as a dysregulated serum lipid response dominated by polyunsaturated fatty acid-containing phosphatidylethanolamine, partially recapitulating cytokine and lipid responses associated with severe human COVID-19. Our data support the hamster model for testing restrictive or targeted diets and immunomodulatory therapies to mediate the adverse effects of metabolic disease on COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Dietary Carbohydrates / Lipid Metabolism / Diet, High-Fat / COVID-19 Type of study: Prognostic study / Risk factors Limits: Animals / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: V13122506

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Dietary Carbohydrates / Lipid Metabolism / Diet, High-Fat / COVID-19 Type of study: Prognostic study / Risk factors Limits: Animals / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: V13122506