Vitamin C Inhibits Angiotensin-Converting Enzyme-2 in Isolated Rat Aortic Ring.
Cardiovasc Hematol Disord Drug Targets
; 21(4): 235-242, 2021.
Article
in English
| MEDLINE | ID: covidwho-1573714
ABSTRACT
AIMS:
The study aimed to assess the inhibitory effect of Vitamin C on angiotensin-converting enzyme 2.BACKGROUND:
Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which uses angiotensin-converting enzyme 2 (ACE-II) as the first route to infect human cells. Accordingly, agents with potential inhibition of ACE-II receptors might be effective in the prevention and management of COVID-19.OBJECTIVE:
The goal of this work was to assess the possible inhibitory effect of ACE-II on ascorbic acid using an ex vivo approach based on the inhibition of diminazene-induced vasorelaxation. MATERIALS ANDMETHODS:
In the present study, diminazene was used as a known specific inhibitor of ACE-II. Then, the vasorelaxant effect of ascorbic acid on diminazene-induced relaxation was examined using isolated aortic rings. All experiments of this study were evaluated on isolated aortic rings precontracted by epinephrine.RESULTS:
The results confirmed that diminazene-induced vasorelaxation in a dose-dependent manner. More interestingly, ascorbic acid inhibited diminazene-induced vasorelaxation in a dose-dependent manner.CONCLUSION:
This investigation provides valuable experimental proof of the efficacy of ascorbic acid (Vitamin C) on inhibiting ex vivo vascular angiotensin-converting enzyme II, which is known among the pharmacological targets of anti-COVID-19 drugs.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Ascorbic Acid
/
COVID-19
Type of study:
Experimental Studies
Limits:
Animals
/
Humans
Language:
English
Journal:
Cardiovasc Hematol Disord Drug Targets
Journal subject:
Vascular Diseases
/
Cardiology
/
Hematology
/
Drug Therapy
Year:
2021
Document Type:
Article
Affiliation country:
1871529X21666211214153308
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