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Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran - a clinical case and global pharmacovigilance data.
Battegay, Raphael; Istampoulouoglou, Ioanna; Holbro, Andreas; Buser, Andreas; Hirsiger, Julia R; Eckstein, Jens; Berger, Christoph T; Koechlin, Sarah; Leuppi-Taegtmeyer, Anne B.
  • Battegay R; Department of Haematology, University Hospital Basel, Switzerland.
  • Istampoulouoglou I; Department of Clinical Pharmacology and Toxicology, University Hospital Basel, Switzerland.
  • Holbro A; Department of Haematology, University Hospital Basel, Switzerland.
  • Buser A; University of Basel, Switzerland.
  • Hirsiger JR; Regional Transfusion Service, Swiss Red Cross, Basel, Switzerland.
  • Eckstein J; Department of Haematology, University Hospital Basel, Switzerland.
  • Berger CT; University of Basel, Switzerland.
  • Koechlin S; Regional Transfusion Service, Swiss Red Cross, Basel, Switzerland.
  • Leuppi-Taegtmeyer AB; University of Basel, Switzerland.
Swiss Med Wkly ; 151: w30084, 2021 12 06.
Article in English | MEDLINE | ID: covidwho-1573820
ABSTRACT
We report the occurrence of immune thrombocytopenia (ITP) in a 77-year-old man a few days after receiving the first dose of the COVID-19 mRNA vaccine tozinameran (Comirnaty®). The patient was treated with systemic corticosteroids, intravenous immunoglobulins and eltrombopag. He elected to proceed with the second dose of tozinameran 14 weeks after the first and his platelet count remained stable under a tapered eltrombopag dose. To our knowledge, this is the first case in which a second tozinameran dose has been administered to a patient who developed presumed secondary ITP after the first vaccination. We also report global pharmacovigilance data for the occurrence of ITP after vaccination with tozinameran.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Purpura, Thrombocytopenic, Idiopathic / COVID-19 Type of study: Case report / Prognostic study Topics: Vaccines Limits: Aged / Humans Language: English Journal: Swiss Med Wkly Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Smw.2021.w30084

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Purpura, Thrombocytopenic, Idiopathic / COVID-19 Type of study: Case report / Prognostic study Topics: Vaccines Limits: Aged / Humans Language: English Journal: Swiss Med Wkly Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Smw.2021.w30084