Clinical characteristics and antibody analysis of COVID-19 patients after SARS-CoV-2 vaccination (Vero cells) administration

ABSTRACT

Objective To analyze the clinical characteristics and antibody of 22 COVID-19 patients with the adsorbed SARS-CoV-2 vaccine innoculation, in order to benefit clinical prediction and treatment. Methods Totally 22 patients with COVID-19 after inactivated vaccination who were admitted to our hospital from December 2020 to March 2021 were selected as the research subjects. Demographic characteristic, clinical symptoms, blood tests, nucleic acids and antibody tests, chest CT and treatment methods were analyzed to figure out the clinical characteristics and antibody changes. Results The median age of 22 patients was 34.5 years old. The clinical symptoms were mainly cough (8 cases), expectoration (3 cases), poor appetite (3 cases), fever (1 case), chest tightness (1 case), throat discomfort(1 case) and nasal congestion and runny nose (1 case). The chest CT mainly showed unilateral pneumonia (2 cases) and bilateral pneumonia (7 cases), presenting as ground glass shadow (5 cases) or ground glass with patch shadow (4 cases). One patient's antibody turned out to be IgM(+)IgG(-), three cases with IgM (-)IgG(-), four with IgM(-)IgG(+) and fourteen with IgM(+)IgG(+) on admission. Conclusion The majority of COVID-19 patients treated by our hospital after inoculation of inactivated SARS-CoV-2 vaccine (Vero cells) are young and middle-aged men, and the clinical classification is mainly common type patients. The clinical symptoms are mainly cough, sputum, fever, throat discomfort, etc., and the chest imaging can show unilateral or bilateral ground glass shadow or patch shadow exudation lesions. The prognosis was good with all patients cured by routine treatment such as oxygen therapy and traditional Chinese medicine. After inoculating inactivated Vero cells, the patients infected with COVID-19 can rapidly produce a large number of IgG antibodies in a short time. © 2021 Editorial Office of Chinese Journal of Schistosomiasis Control. All right reserved.