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Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia.
Dashdorj, Naranjargal J; Wirz, Oliver F; Röltgen, Katharina; Haraguchi, Emily; Buzzanco, Anthony S; Sibai, Mamdouh; Wang, Hannah; Miller, Jacob A; Solis, Daniel; Sahoo, Malaya K; Arunachalam, Prabhu S; Lee, Alexandra S; Shah, Mihir M; Liu, James; Byambabaatar, Sumiya; Bat-Ulzii, Purevjargal; Enkhbat, Anir; Batbold, Enkhtuul; Zulkhuu, Delgersaikhan; Ochirsum, Byambasuren; Khurelsukh, Tungalag; Dalantai, Ganbold; Burged, Natsagdorj; Baatarsuren, Uurtsaikh; Ariungerel, Nomin; Oidovsambuu, Odgerel; Bungert, Andreas S; Genden, Zulkhuu; Yagaanbuyant, Dahgwahdorj; Mordorj, Altankhuu; Pulendran, Bali; Chinthrajah, Sharon; Nadeau, Kari C; Jardetzky, Theodore; Wilbur, James L; Wohlstadter, Jacob N; Sigal, George B; Pinsky, Benjamin A; Boyd, Scott D; Dashdorj, Naranbaatar D.
  • Dashdorj NJ; Onom Foundation, Ulaanbaatar 17013, Mongolia; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Wirz OF; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Röltgen K; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Haraguchi E; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Buzzanco AS; Department of Structural Biology, Stanford University, Stanford, CA 94305, USA.
  • Sibai M; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Wang H; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Miller JA; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Solis D; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Sahoo MK; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Arunachalam PS; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.
  • Lee AS; Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA.
  • Shah MM; Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA.
  • Liu J; Stanford Health Library, Stanford, CA 94304, USA.
  • Byambabaatar S; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Bat-Ulzii P; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Enkhbat A; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Batbold E; Onom Foundation, Ulaanbaatar 17013, Mongolia; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Zulkhuu D; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Ochirsum B; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Khurelsukh T; National Center for Zoonotic Diseases, Ulaanbaatar 18131, Mongolia.
  • Dalantai G; National Center for Zoonotic Diseases, Ulaanbaatar 18131, Mongolia.
  • Burged N; National Center for Zoonotic Diseases, Ulaanbaatar 18131, Mongolia.
  • Baatarsuren U; Onom Foundation, Ulaanbaatar 17013, Mongolia.
  • Ariungerel N; Onom Foundation, Ulaanbaatar 17013, Mongolia.
  • Oidovsambuu O; Onom Foundation, Ulaanbaatar 17013, Mongolia; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Bungert AS; Onom Foundation, Ulaanbaatar 17013, Mongolia.
  • Genden Z; Onom Foundation, Ulaanbaatar 17013, Mongolia; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Yagaanbuyant D; Onom Foundation, Ulaanbaatar 17013, Mongolia; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Mordorj A; Onom Foundation, Ulaanbaatar 17013, Mongolia; Liver Center, Ulaanbaatar 14230, Mongolia.
  • Pulendran B; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA.
  • Chinthrajah S; Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA; Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.
  • Nadeau KC; Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA; Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA 94305, USA.
  • Jardetzky T; Department of Structural Biology, Stanford University, Stanford, CA 94305, USA.
  • Wilbur JL; Meso Scale Diagnostics, Rockville, MD 20850, USA.
  • Wohlstadter JN; Meso Scale Diagnostics, Rockville, MD 20850, USA.
  • Sigal GB; Meso Scale Diagnostics, Rockville, MD 20850, USA.
  • Pinsky BA; Department of Pathology, Stanford University, Stanford, CA 94305, USA.
  • Boyd SD; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94305, USA. Electronic address: sboyd1@stanford.edu.
  • Dashdorj ND; Onom Foundation, Ulaanbaatar 17013, Mongolia.
Cell Host Microbe ; 29(12): 1738-1743.e4, 2021 12 08.
Article in English | MEDLINE | ID: covidwho-1574127
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Different SARS-CoV-2 vaccines are approved in various countries, but few direct comparisons of the antibody responses they stimulate have been reported. We collected plasma specimens in July 2021 from 196 Mongolian participants fully vaccinated with one of four COVID-19 vaccines Pfizer/BioNTech, AstraZeneca, Sputnik V, and Sinopharm. Functional antibody testing with a panel of nine SARS-CoV-2 viral variant receptor binding domain (RBD) proteins revealed marked differences in vaccine responses, with low antibody levels and RBD-ACE2 blocking activity stimulated by the Sinopharm and Sputnik V vaccines in comparison to the AstraZeneca or Pfizer/BioNTech vaccines. The Alpha variant caused 97% of infections in Mongolia in June and early July 2021. Individuals who recover from SARS-CoV-2 infection after vaccination achieve high antibody titers in most cases. These data suggest that public health interventions such as vaccine boosting, potentially with more potent vaccine types, may be needed to control COVID-19 in Mongolia and worldwide.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mass Vaccination / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2021 Document Type: Article Affiliation country: J.chom.2021.11.004

Full text: Available Collection: International databases Database: MEDLINE Main subject: Mass Vaccination / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2021 Document Type: Article Affiliation country: J.chom.2021.11.004