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Current HLA Investigations on SARS-CoV-2 and Perspectives.
Douillard, Venceslas; Castelli, Erick C; Mack, Steven J; Hollenbach, Jill A; Gourraud, Pierre-Antoine; Vince, Nicolas; Limou, Sophie.
  • Douillard V; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.
  • Castelli EC; Unesp - Universidade Estadual Paulista, Botucatu-SP, Brazil.
  • Mack SJ; Division of Allergy, Immunology and Bone Marrow Transplantation, Department of Pediatrics, School of Medicine, University of California, San Francisco, CA, United States.
  • Hollenbach JA; Department of Neurology, University of California, San Francisco and Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States.
  • Gourraud PA; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.
  • Vince N; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.
  • Limou S; Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.
Front Genet ; 12: 774922, 2021.
Article in English | MEDLINE | ID: covidwho-1574199
ABSTRACT
The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics' interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Genet Year: 2021 Document Type: Article Affiliation country: Fgene.2021.774922

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Genet Year: 2021 Document Type: Article Affiliation country: Fgene.2021.774922