Periodontal tissues are targets for Sars-Cov-2: a post-mortem study.
J Oral Microbiol
; 13(1): 1848135, 2020 Nov 26.
Article
in English
| MEDLINE | ID: covidwho-1574293
ABSTRACT
Background:
The ability of coronavirus SARS-CoV-2 to spread is one of the determinants of the COVID-19 pandemic status. Until June 2020, global COVID-19 cases surpassed 10 million. Asymptomatic patients, with no respiratory impairment, are believed to be responsible for more than 80% of the transmission. Other viruses have been consistently detected in periodontal tissues.Objective:
The aim of this study was to investigate the presence of SARS-CoV-2 in periodontal tissue.Methods:
We conducted video-endoscope minimally invasive post-mortem biopsy in seven fatal cases of COVID-19, using a regular endoscope video system associated with a smartphone to locate periodontal tissue. We analyzed the samples using RT-PCR, to identify the SARS-CoV-2 RNA and histopathological analysis.Results:
The seven studied autopsies with positive laboratory tests for COVID-19 included 57.14% of female patients at the average age of 47.4 (range 8 to 74). In five cases, periodontal tissue was positive for SARS-CoV-2 (RT-PCR). Histopathologic analyses showed morphologic alterations in the keratinocytes of the junctional epithelium, a vacuolization of the cytoplasm and nucleus and nuclear pleomorphism.Conclusion:
We presented a biomolecular analysis obtained from minimally invasive autopsies. This is the first study to demonstrate the presence of SARS-CoV-2 in periodontal tissue in COVID-19 positive patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
J Oral Microbiol
Year:
2020
Document Type:
Article
Affiliation country:
20002297.2020.1848135
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