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Brief Report: Impact of the COVID-19 Pandemic on Virological Suppression in People Living With HIV Attending a Large Italian HIV Clinic.
Giacomelli, Andrea; Bonazzetti, Cecilia; Conti, Federico; Pezzati, Laura; Oreni, Letizia; Micheli, Valeria; Mancon, Alessandro; Vimercati, Stefania; Albrecht, Maria; Passerini, Matteo; Cossu, Maria Vittoria; Capetti, Amedeo Ferdinando; Meraviglia, Paola; Antinori, Spinello; Rizzardini, Giuliano; Galli, Massimo; Ridolfo, Anna Lisa.
  • Giacomelli A; III Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Bonazzetti C; III Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Conti F; Luigi Sacco Department of Biomedical and Clinical Sciences DIBIC, University of Milan, Milan, Italy.
  • Pezzati L; III Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Oreni L; Luigi Sacco Department of Biomedical and Clinical Sciences DIBIC, University of Milan, Milan, Italy.
  • Micheli V; III Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Mancon A; Luigi Sacco Department of Biomedical and Clinical Sciences DIBIC, University of Milan, Milan, Italy.
  • Vimercati S; III Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Albrecht M; Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli- Sacco, Luigi Sacco University Hospital, Milan, Italy.
  • Passerini M; Laboratory of Clinical Microbiology, Virology and Bioemergencies, ASST Fatebenefratelli- Sacco, Luigi Sacco University Hospital, Milan, Italy.
  • Cossu MV; Pharmaceutical Department, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Capetti AF; Pharmaceutical Department, ASST Fatebenefratelli-Sacco, Milan, Italy.
  • Meraviglia P; I Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.
  • Antinori S; Luigi Sacco Department of Biomedical and Clinical Sciences DIBIC, University of Milan, Milan, Italy.
  • Rizzardini G; I Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.
  • Galli M; I Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.
  • Ridolfo AL; I Infectious Diseases Unit, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.
J Acquir Immune Defic Syndr ; 88(3): 299-304, 2021 11 01.
Article in English | MEDLINE | ID: covidwho-1574388
ABSTRACT

BACKGROUND:

We assessed the impact of the coronavirus disease 2019 (COVID-19) pandemic on HIV suppression rates in people living with HIV (PLWH) attending a large Italian HIV clinic.

SETTING:

The HIV outpatient clinic of the Infectious Diseases Department of Luigi Sacco Hospital, Milan, Italy, which serves more than 5000 PLWH per year.

METHODS:

A before and after quasi-experimental study design was used to make a retrospective assessment of the monthly trend of HIV-RNA determinations of ≥50 among the PLWH attending our clinic, with "before" being the period from January 1, 2016 to February 20, 2020, and "after" being the period from February 21, 2020 to December 31, 2020 (the COVID-19 period). Interrupted time series analysis was used to evaluate any changes in the trend.

RESULTS:

During the study period, 70,349 HIV-RNA viral load determinations were made, and the percentage of HIV-RNA viral load determinations of <50 copies/mL increased from 88.4% in 2016 to 93.2% in 2020 (P < 0.0001). There was a significant monthly trend toward a decrease in the number of HIV-RNA determinations of ≥50 copies/mL before the pandemic (ß -0.084; standard error 0.015; P < 0.001), and this did not significantly change after it started (ß -0.039, standard error 0.161; P = 0.811).

CONCLUSIONS:

A high prevalence of viral suppression was maintained among the PLWH referring to our clinic, despite the structural barriers raised by the COVID-19 pandemic. The use of simplified methods of delivering care (such as teleconsultations and multiple antiretroviral treatment prescriptions) may have contributed to preserving this continuum.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Anti-HIV Agents / COVID-19 Type of study: Risk factors Limits: Humans Country/Region as subject: Europa Language: English Journal: J Acquir Immune Defic Syndr Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2021 Document Type: Article Affiliation country: QAI.0000000000002754

Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections / Anti-HIV Agents / COVID-19 Type of study: Risk factors Limits: Humans Country/Region as subject: Europa Language: English Journal: J Acquir Immune Defic Syndr Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2021 Document Type: Article Affiliation country: QAI.0000000000002754