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Changes in serum virus-specific IgM/IgG antibody in asymptomatic and discharged patients with reoccurring positive COVID-19 nucleic acid test (RPNAT).
Liu, Junli; Lian, Rui; Zhang, Guochao; Hou, Baojun; Wang, Chuming; Dong, Jian; Yang, Liu; Wang, Jianglan; Dai, Shangming; Chen, Libo; Zhang, Guoqiang; Lu, Xin; Ye, Ting.
  • Liu J; Laboratory Department, Union Jiangbei Hospital, Wuhan, China.
  • Lian R; Emergency Department, China-Japan Friendship Hospital, Beijing, China.
  • Zhang G; General Surgery Department, China-Japan Friendship Hospital, Beijing, China.
  • Hou B; Endocrinology Department, Union Jiangbei Hospital, Wuhan, China.
  • Wang C; Laboratory Department, Union Jiangbei Hospital, Wuhan, China.
  • Dong J; Respiratory Department, Union Jiangbei Hospital, Wuhan, China.
  • Yang L; Laboratory Department, Union Jiangbei Hospital, Wuhan, China.
  • Wang J; Laboratory Department, Union Jiangbei Hospital, Wuhan, China.
  • Dai S; Laboratory Department, Union Jiangbei Hospital, Wuhan, China.
  • Chen L; Emergency Department, Union Jiangbei Hospital, Wuhan, China.
  • Zhang G; Emergency Department, China-Japan Friendship Hospital, Beijing, China.
  • Lu X; Rheumatology and Immunology Department, Friendship Hospital, Beijing, China.
  • Ye T; Wuhan First Bioscience Co, Ltd, Wuhan, China.
Ann Med ; 53(1): 34-42, 2021 12.
Article in English | MEDLINE | ID: covidwho-1574894
ABSTRACT

BACKGROUND:

Studies have demonstrated the diagnostic efficiency of antibody testing in COVID-19 infection. There is limited data on the IgM/IgG changes in asymptomatic and discharged patients with reoccurring positive nucleic acid test (RPNAT). This study aims to investigate these IgM/IgG changes.

METHODS:

There were 111 patients with positive nucleic acid test (NAT) and 40 suspected patients enrolled in the study. The serum SARS-CoV-2 specific IgM/IgG antibody levels were retrospectively analysed with the disease progress in asymptomatic and RPNAT patients.

RESULTS:

The best overall performance was found by combining the IgM, IgG, and CT; 95.1% sensitivity and 75% specificity. This was tested in 111 RT-PCR positive cases. The median IgM and IgG levels were lower in the asymptomatic group compared to the symptomatic group (p < .01). Among 15 RPNAT cases, the IgM levels of the RPNAT group at the time of discharge (IgM2.79, IQR 0.95-5.37) and retest (IgM 2.35, IQR 0.88-8.65) were significantly higher than those of the non-reoccurring positive nucleic acid test group (Non-RPNAT) (IgM on discharge 0.59, IQR 0.33-1.22, IgG on retest 0.92, IQR 0.51-1.58).

CONCLUSION:

Serum SARS-CoV-2 specific IgM/IgG antibody levels remained at a low level during hospitalisation for asymptomatic patients. Elevated IgM levels may have implications in the identification of RPNAT patients before discharge. Key messages This study determined the IgM/IgG changes in asymptomatic and RPNAT patients. The rate of serum SARS-CoV-2 specific IgM/IgG antibody levels increase in the asymptomatic group was lower than in the symptomatic group during hospitalisation. The IgM level did not decrease significantly at discharge in the RPNAT patients, and was higher than that of the Non-RPNAT group on discharge. These results highlight the importance of timely monitoring of IgM levels to identify RPNAT patients before discharge.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Immunoglobulin G / Immunoglobulin M / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Observational study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Ann Med Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: 07853890.2020.1811887

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Immunoglobulin G / Immunoglobulin M / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Observational study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Ann Med Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: 07853890.2020.1811887