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Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings.
Midha, Ish K; Kumar, Nilesh; Kumar, Amit; Madan, Taruna.
  • Midha IK; Pentamed Hospital, New Delhi, India.
  • Kumar N; Saint Vincent Hospital, Worcester, Massachusetts, USA.
  • Kumar A; Dwight D. Eisenhower VA Medical Center, Leavenworth, Kansas, USA.
  • Madan T; Department of Innate Immunity, ICMR-National Institute for Research in Reproductive Health, Mumbai, India.
Rev Med Virol ; 31(5): 1-14, 2021 09.
Article in English | MEDLINE | ID: covidwho-1575050
ABSTRACT
Of all the nutrients, vitamin A has been the most extensively evaluated for its impact on immunity. There are three main forms of vitamin A, retinol, retinal and retinoic acid (RA) with the latter being most biologically active and all-trans-RA (ATRA) its main derivative. Vitamin A is a key regulator of the functions of various innate and adaptive immune cells and promotes immune-homeostasis. Importantly, it augments the interferon-based innate immune response to RNA viruses decreasing RNA virus replication. Several clinical trials report decreased mortality in measles and Ebola with vitamin A supplementation.During the Covid-19 pandemic interventions such as convalescent plasma, antivirals, monoclonal antibodies and immunomodulator drugs have been tried but most of them are difficult to implement in resource-limited settings. The current review explores the possibility of mega dose vitamin A as an affordable adjunct therapy for Covid-19 illness with minimal reversible side effects. Insight is provided into the effect of vitamin A on ACE-2 expression in the respiratory tract and its association with the prognosis of Covid-19 patients. Vitamin A supplementation may aid the generation of protective immune response to Covid-19 vaccines. An overview of the dosage and safety profile of vitamin A is presented along with recommended doses for prophylactic/therapeutic use in randomised controlled trials in Covid-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin A / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2204

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin A / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2204