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Male reproductive system inflammation after healing from coronavirus disease 2019.
Morselli, Simone; Sebastianelli, Arcangelo; Liaci, Andrea; Zaccaro, Claudia; Pecoraro, Alessio; Nicoletti, Rossella; Manera, Alekseja; Bisegna, Claudio; Campi, Riccardo; Pollini, Simona; Antonelli, Alberto; Lagi, Filippo; Coppi, Marco; Baldi, Elisabetta; Marchiani, Sara; Nicolò, Sabrina; Torcia, Maria; Annunziato, Francesco; Maggi, Mario; Vignozzi, Linda; Bartoloni, Alessandro; Rossolini, Gian Maria; Serni, Sergio; Gacci, Mauro.
  • Morselli S; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Sebastianelli A; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Liaci A; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Zaccaro C; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Pecoraro A; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Nicoletti R; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Manera A; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Bisegna C; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Campi R; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Pollini S; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Antonelli A; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Lagi F; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Coppi M; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Baldi E; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Marchiani S; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Nicolò S; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Torcia M; Department of Minimally Invasive and Robotic Urologic Surgery and Kidney Transplantation, Careggi University Hospital (AOUC), University of Florence, Florence, Italy.
  • Annunziato F; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Maggi M; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Vignozzi L; Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, University of Florence, Florence, Italy.
  • Bartoloni A; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Rossolini GM; Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, University of Florence, Florence, Italy.
  • Serni S; Department of Experimental and Clinical Medicine, University of Florence, University of Florence, Florence, Italy.
  • Gacci M; Infectious and Tropical Diseases Unit, Careggi University Hospital, University of Florence, Florence, Italy.
Andrology ; 10(6): 1030-1037, 2022 09.
Article in English | MEDLINE | ID: covidwho-1575098
ABSTRACT

BACKGROUND:

There is evidence that, after severe acute respiratory syndrome coronavirus 2 infection, male reproductive function and semen quality may be damaged

OBJECTIVES:

To evaluate a panel of inflammatory mediators in semen in patients recovered from coronavirus disease 2019. MATERIAL AND

METHODS:

Sexually active men with previous severe acute respiratory syndrome coronavirus 2 infection and proven recovery from coronavirus disease 2019 were enrolled in a prospective cohort study. Clinical, uro-andrological data and semen specimens were prospectively collected. For previously hospitalized coronavirus disease 2019 patients, data on serum inflammatory markers were retrospectively collected.

RESULTS:

A total of 43 men were enrolled in the study. Of these, 32 men were normozoospermic, three were oligozoospermic, and eight were crypto-azoospermic. Serum inflammatory markers (procalcitonin and C-reactive protein) were analyzed in previously hospitalized patients both at admission and at peak of infection. Levels at admission were statistically significantly higher in patients resulting in crypto-azoospermic with respect to those resulting in normozoospermic (p = 0.05; p = 0.03 and p = 0.02, respectively) after healing. Seminal cytokine levels were similar among all groups. Interleukin-1ß and tumor necrosis factor-α levels were significantly negatively related to sperm total number and concentration, whereas interleukin-4 was correlated with sperm motility. DISCUSSION AND

CONCLUSION:

Negative correlations between interleukin-1ß and tumor necrosis factor-α and sperm number and the overall high levels of semen cytokines indicate a potential detrimental role of severe acute respiratory syndrome coronavirus 2 driven inflammation on spermatogenesis. Overall, our results indicate that male patients recovering from coronavirus disease 2019 deserve accurate follow-up for their fertility status.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Azoospermia / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Humans / Male Language: English Journal: Andrology Year: 2022 Document Type: Article Affiliation country: Andr.13138

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Azoospermia / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Humans / Male Language: English Journal: Andrology Year: 2022 Document Type: Article Affiliation country: Andr.13138