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C-reactive protein as an effector molecule in Covid-19 pathogenesis.
Mosquera-Sulbaran, Jesús A; Pedreañez, Adriana; Carrero, Yenddy; Callejas, Diana.
  • Mosquera-Sulbaran JA; Instituto de Investigaciones Clinicas "Dr. Americo Negrette", Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
  • Pedreañez A; Catedra de Inmunologia, Escuela de Bioanalisis, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
  • Carrero Y; Facultad de Ciencias de la Salud, Carrera de Medicina, Universidad Tecnica de Ambato, Ambato, Ecuador.
  • Callejas D; Facultad de Ciencias de la Salud, Departamento de Ciencias Biologicas, Universidad Tecnica de Manabi, Portoviejo, Ecuador.
Rev Med Virol ; 31(6): e2221, 2021 11.
Article in English | MEDLINE | ID: covidwho-1575100
ABSTRACT
The current pandemic caused by SARS-CoV-2 virus infection is known as Covid-19 (coronavirus disease 2019). This disease can be asymptomatic or can affect multiple organ systems. Damage induced by the virus is related to dysfunctional activity of the immune system, but the activity of molecules such as C-reactive protein (CRP) as a factor capable of inducing an inflammatory status that may be involved in the severe evolution of the disease, has not been extensively evaluated. A systematic review was performed using the NCBI-PubMed database to find articles related to Covid-19 immunity, inflammatory response, and CRP published from December 2019 to December 2020. High levels of CRP were found in patients with severe evolution of Covid-19 in which several organ systems were affected and in patients who died. CRP activates complement, induces the production of pro-inflammatory cytokines and induces apoptosis which, together with the inflammatory status during the disease, can lead to a severe outcome. Several drugs can decrease the level or block the effect of CRP and might be useful in the treatment of Covid-19. From this review it is reasonable to conclude that CRP is a factor that can contribute to severe evolution of Covid-19 and that the use of drugs able to lower CRP levels or block its activity should be evaluated in randomized controlled clinical trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: C-Reactive Protein / Complement System Proteins / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Anti-Inflammatory Agents Type of study: Controlled clinical trial / Etiology study / Randomized controlled trials / Reviews / Systematic review Limits: Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2221

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Full text: Available Collection: International databases Database: MEDLINE Main subject: C-Reactive Protein / Complement System Proteins / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Anti-Inflammatory Agents Type of study: Controlled clinical trial / Etiology study / Randomized controlled trials / Reviews / Systematic review Limits: Humans Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2221