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Minimizing the impact of the triple burden of COVID-19, tuberculosis and HIV on health services in sub-Saharan Africa.
Nachega, Jean B; Kapata, Nathan; Sam-Agudu, Nadia A; Decloedt, Eric H; Katoto, Patrick D M C; Nagu, Tumaini; Mwaba, Peter; Yeboah-Manu, Dorothy; Chanda-Kapata, Pascalina; Ntoumi, Francine; Geng, Elvin H; Zumla, Alimuddin.
  • Nachega JB; Department of Medicine and Center for Infectious Diseases, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, South Africa; Department of Epidemiology, Infectious Diseases and Microbiology, and Center for Global Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  • Kapata N; Zambia National Public Health Institute, University of Zambia-University College London Medical School Research and Training Project, University Teaching Hospital, Ministry of Health, Lusaka, Zambia. Electronic address: nkapata@gmail.com.
  • Sam-Agudu NA; International Research Center of Excellence, Institute of Human Virology Nigeria, Abuja, Nigeria; Institute of Human Virology and Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Pediatrics and Child Health, School of Medical Sciences, Univ
  • Decloedt EH; Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa. Electronic address: ericdecloedt@sun.ac.za.
  • Katoto PDMC; Department of Medicine and Center for Infectious Diseases, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, South Africa. Electronic address: katotopatrick@gmail.com.
  • Nagu T; School of Medicine, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania. Electronic address: jtjoyce20@gmail.com.
  • Mwaba P; Lusaka Apex Medical University, Lusaka, Zambia. Electronic address: pbmwaba2000@gmail.com.
  • Yeboah-Manu D; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. Electronic address: DYeboah-Manu@noguchi.ug.edu.gh.
  • Chanda-Kapata P; Ministry of Health, Lusaka, Zambia. Electronic address: pascykapata@gmail.com.
  • Ntoumi F; Fondation Congolaise pour la Recherche Médicale (FCRM), Brazzaville, Congo; Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany. Electronic address: fntoumi@fcrm-congo.com.
  • Geng EH; Division of Infectious Diseases, Department of Medicine, and Center for Dissemination and Implementation, Institute for Public Health, Washington University, St Louis, Missouri, USA. Electronic address: elvin.geng@wustl.edu.
  • Zumla A; Division of Infection and Immunity, University College London, London, UK; NIHR Biomedical Research Centre, University College London Hospitals, London, UK. Electronic address: a.zumla@ucl.ac.uk.
Int J Infect Dis ; 113 Suppl 1: S16-S21, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1575135
ABSTRACT
In this perspective, we discuss the impact of COVID-19 on tuberculosis (TB)/HIV health services and approaches to mitigating the growing burden of these three colliding epidemics in sub-Saharan Africa (SSA). SSA countries bear significantly high proportions of TB and HIV cases reported worldwide, compared to countries in the West. Whilst COVID-19 epidemiology appears to vary across Africa, most countries in this region have reported relatively lower-case counts compared to the West. Nevertheless, the COVID-19 pandemic has added an additional burden to already overstretched health systems in SSA, which, among other things, have been focused on the longstanding dual epidemics of TB and HIV. As with these dual epidemics, inadequate resources and poor case identification and reporting may be contributing to underestimations of the COVID-19 case burden in SSA. Modelling studies predict that the pandemic-related disruptions in TB and HIV services will result in significant increases in associated morbidity and mortality over the next five years. Furthermore, limited empirical evidence suggests that SARS-CoV-2 coinfections with TB and HIV are associated with increased mortality risk in SSA. However, predictive models require a better evidence-base to accurately define the impact of COVID-19, not only on communicable diseases such as TB and HIV, but on non-communicable disease comorbidities. Further research is needed to assess morbidity and mortality data among both adults and children across the African continent, paying attention to geographic disparities, as well as the clinical and socio-economic determinants of COVID-19 in the setting of TB and/or HIV.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / HIV Infections / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Child / Humans Country/Region as subject: Africa Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.03.038

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / HIV Infections / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Child / Humans Country/Region as subject: Africa Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: J.ijid.2021.03.038