miR-495 Regulates Cellular Reactive Oxygen Species Levels by Targeting sod2 To Inhibit Intracellular Survival of Mycobacterium tuberculosis in Macrophages.
Infect Immun
; 89(12): e0031521, 2021 11 16.
Article
in English
| MEDLINE | ID: covidwho-1575412
ABSTRACT
Mycobacterium tuberculosis is a chronic infectious disease pathogen. To date, tuberculosis is a major infectious disease that endangers human health. To better prevent and treat tuberculosis, it is important to study the pathogenesis of M. tuberculosis. Based on early-stage laboratory research results, in this study, we verified the upregulation of sod2 in Bacillus Calmette-Guérin (BCG) and H37Rv infection. By detecting BCG/H37Rv intracellular survival in sod2-silenced and sod2-overexpressing macrophages, sod2 was found to promote the intracellular survival of BCG/H37Rv. miR-495 then was determined to be downregulated by BCG/H37Rv. BCG/H37Rv can upregulate sod2 expression by miR-495 to promote the intracellular survival of BCG/H37Rv through a decline in ROS levels. This study provides a theoretical basis for developing new drug targets and treating tuberculosis.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Superoxide Dismutase
/
Tuberculosis
/
Reactive Oxygen Species
/
MicroRNAs
/
Macrophages
/
Mycobacterium tuberculosis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Infect Immun
Year:
2021
Document Type:
Article
Affiliation country:
IAI.00315-21
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