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Thrombotic and Hemorrhagic Incidences in Patients After Discharge from COVID-19 Infection: A Systematic Review and Meta-Analysis.
Rungjirajittranon, Tarinee; Owattanapanich, Weerapat; Leelakanok, Nattawut; Sasijareonrat, Natthaporn; Suwanawiboon, Bundarika; Chinthammitr, Yingyong; Ruchutrakool, Theera.
  • Rungjirajittranon T; 26685Mahidol University, Bangkok, Thailand.
  • Owattanapanich W; 26685Mahidol University, Bangkok, Thailand.
  • Leelakanok N; 577110Burapha University, Chonburi, Thailand.
  • Sasijareonrat N; 67993Bangkok Metropolitan Administration (BMA) General Hospital, Bangkok, Thailand.
  • Suwanawiboon B; 26685Mahidol University, Bangkok, Thailand.
  • Chinthammitr Y; 26685Mahidol University, Bangkok, Thailand.
  • Ruchutrakool T; 26685Mahidol University, Bangkok, Thailand.
Clin Appl Thromb Hemost ; 27: 10760296211069082, 2021.
Article in English | MEDLINE | ID: covidwho-1575453
ABSTRACT

BACKGROUND:

The association between coronavirus infection 2019 (COVID-19) and thrombosis has been explicitly shown through numerous reports that demonstrate high rates of thrombotic complications in infected patients. Recently, much evidence has shown that patients who survived COVID-19 might have a high thrombotic risk after hospital discharge. This current systematic review and meta-analysis was conducted to better understand the incidence of thrombosis, bleeding, and mortality rates among patients discharged after COVID-19 hospitalization.

METHODS:

Using a search strategy that included terms for postdischarge, thrombosis, and COVID-19, 2 investigators independently searched for published articles indexed in the MEDLINE, Embase, and Scopus databases that were published before August 2021. Pooled incidences and 95% confidence intervals were calculated using the DerSimonian-Laird random-effects model with a double arcsine transformation.

RESULTS:

Twenty articles were included in the meta-analysis. They provided a total of 19 461 patients discharged after COVID-19 hospitalization. The weighted pooled incidence of overall thrombosis among the patients was 1.3% (95 CI, 0. 6-2; I2 90.5), with a pooled incidence of venous thrombosis of 0.7% (95 CI, 0. 4-1; I2 73.9) and a pooled incidence of arterial thrombosis of 0.6% (95 CI, 0. 2-1; I2 88.1). The weighted pooled incidences of bleeding and mortality were 0.9% (95 CI, 0. 1-1.9; I2 95.1) and 2.8% (95 CI, 0. 6-5; I2 98.2), respectively.

CONCLUSIONS:

The incidences of thrombosis and bleeding in patients discharged after COVID-19 hospitalization are comparable to those of medically ill patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / COVID-19 / Hemorrhage Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: 10760296211069082

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / COVID-19 / Hemorrhage Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2021 Document Type: Article Affiliation country: 10760296211069082