COVID-19-associated multisystem inflammatory syndrome in children: Experiences of three centres in Turkey.
Mod Rheumatol
; 32(2): 460-466, 2022 Feb 28.
Article
in English
| MEDLINE | ID: covidwho-1575484
ABSTRACT
BACKGROUND:
The pathogenesis and clinical manifestations of the multisystem inflammatory syndrome in children (MIS-C) has not yet been fully elucidated and there is no clear consensus on its treatment yet.OBJECTIVES:
To evaluate our patients diagnosed with MIS-C and present them to the literature in order to contribute to the better understanding of this new disease, which entered paediatric practice with the SARS-CoV-2 peak.METHODS:
In this study, 17 MIS-C cases diagnosed according to the Centers for Disease Control and Prevention criteria were included.RESULTS:
Of the patients, 7 (41.2%) had a comorbidity. Gastrointestinal system involvement was the most prominent in the patients (70.6%). Laparotomy was performed in 3 patients due to acute abdomen. Two patients had neurological involvement. Of the patients, 15 (88.2%) received intravenous immunoglobulin and 13 (76.5%) received both intravenous immunoglobulin and methylprednisolone. Two patients received invasive mechanical ventilation and 4 patients received high flow rate nasal cannula oxygen therapy. One of our patients who needed invasive mechanical ventilation and high vasoactive-inotrope support died despite all supportive treatments including plasmapheresis and extracorporeal membrane oxygenation.CONCLUSIONS:
MIS-C picture can have a fatal course and may present with severe gastrointestinal and neurological signs. Unnecessary laparotomy should be avoided.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Qualitative research
Topics:
Long Covid
Limits:
Child
/
Humans
Country/Region as subject:
North America
/
Asia
Language:
English
Journal:
Mod Rheumatol
Year:
2022
Document Type:
Article
Affiliation country:
Mr
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